This study focuses on preventing Graft Versus Host Disease, a condition that can occur after stem cell transplantation from an unrelated donor. The study will involve patients with various blood disorders including Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Chronic Myelomonocytic Leukemia. The purpose is to compare two different approaches to prevent complications after transplantation.
The study will use several medications including cyclophosphamide, mycophenolate mofetil, and tacrolimus. One group of patients will receive Grafalon, which contains antibodies that affect the immune system, while another group will receive a different combination of medications. These medications will be given through infusion into a vein or taken by mouth.
The treatment will be given around the time of the stem cell transplantation. Patients will receive their assigned medications according to a specific schedule, with some treatments lasting a few days and others continuing for several months. The medications are used to help the body accept the transplanted cells and prevent rejection.
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