This study focuses on Multiple Sclerosis (MS), a condition that affects the central nervous system. The research uses two imaging substances: 18F-DPA-714, a specialized radioactive tracer, and DOTAREM, a contrast agent. These substances help create detailed images of inflammation in the brain using special scanning techniques.
The main purpose is to measure ongoing inflammation in brain lesions of people with MS by using PET imaging (a specialized type of medical scan). The study will compare brain scans of MS patients to those of healthy individuals to better understand how the disease affects brain tissue. During the study, participants will receive the imaging substances through intravenous infusion (delivery directly into a vein).
The research specifically looks at areas of damage in the white matter of the brain, which is commonly affected in MS. Participants will undergo brain imaging sessions where both imaging substances will be used to create detailed pictures of inflammation patterns. This will help researchers better understand how MS affects different areas of the brain and how the disease progresses over time.
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