Aspergillus Fumigatus

This article discusses clinical trials involving the use of Aspergillus Fumigatus, a type of mold, in allergy testing. While the main focus of the trial is on house dust mite allergies, Aspergillus Fumigatus is mentioned as part of a skin prick test solution. This information is valuable for patients interested in understanding allergy testing procedures and the various allergens involved in such tests.

Table of Contents

What is Aspergillus Fumigatus?

Aspergillus fumigatus is a type of mold fungus that is commonly found in the environment. In the context of medical treatment, it is used as an allergen extract for diagnostic purposes[1]. This substance is specifically used in allergy testing to identify if a person is allergic to this particular type of mold.

Medical Uses

The primary medical use of Aspergillus fumigatus in the context provided is for diagnostic purposes, specifically in allergy testing. It is used in a procedure called a skin prick test, which helps doctors determine if a patient is allergic to this specific type of mold[1].

Aspergillus fumigatus is classified under the ATC code V01AA04, which stands for “Mould fungus and yeast fungus” in the context of allergen extracts for diagnostic use[1]. This classification indicates that it’s used primarily for identifying allergies related to mold and yeast fungi.

Administration Method

The Aspergillus fumigatus allergen extract is administered via a skin prick test. This test involves applying a small amount of the allergen solution to the skin, usually on the forearm or back, and then lightly pricking or scratching the skin to allow the solution to enter just below the surface[1].

The solution is typically provided in a dropper bottle, with the dosage usually being one drop per test. The maximum daily dose and total dose are both listed as 1 drop (Gtt)[1].

Allergic Reactions and Testing

If a person is allergic to Aspergillus fumigatus, they may develop a small, itchy bump or wheal at the site of the skin prick test within about 15-20 minutes. The size of this reaction helps doctors determine the severity of the allergy.

It’s important to note that Aspergillus fumigatus is just one of many allergens that might be tested during a comprehensive allergy screening. Other common allergens tested may include:

  • House dust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae)[1]
  • Animal dander (like cat and dog epithelia)[1]
  • Grass and tree pollens[1]

Safety Considerations

While skin prick tests are generally safe, they should always be performed under medical supervision. This is because there’s a small risk of a more severe allergic reaction. Healthcare providers will have emergency medications on hand just in case[1].

It’s crucial for patients to inform their healthcare provider about all medications they’re taking before the test, as some medications can interfere with the results. Additionally, patients with certain skin conditions or who are pregnant may need to postpone the test or consider alternative allergy testing methods[1].

Aspect Details
Drug Name HAL Allergy Prick Test Aspergillus Fumigatus
Purpose Allergy testing (skin prick test)
Form Solution for skin-prick test
Active Substance Aspergillus Fumigatus
Authorization Country Germany
Manufacturer HAL Allergy B.V.
Route of Administration Cutaneous use
Maximum Daily Dose 1 drop
ATC Code V01AA04 (Mould fungus and yeast fungus)

Ongoing Clinical Trials on Aspergillus Fumigatus

  • Study on the Effectiveness of PURETHAL Mites for Adults with Moderate to Severe Allergic Rhinitis or Rhinoconjunctivitis Due to House Dust Mite Allergy

    Not recruiting

    3 1 1
    Austria Bulgaria Germany Latvia Lithuania Poland

Glossary

  • Aspergillus Fumigatus: A type of mold fungus that can cause allergic reactions in some people. It is used in allergy testing to identify specific mold allergies.
  • Skin Prick Test: A method used to diagnose allergies by applying small amounts of allergen solutions to the skin and observing for reactions.
  • Allergen: A substance that can cause an allergic reaction in some people, such as pollen, dust mites, or mold spores.
  • Cutaneous Use: Application on or relating to the skin. In this context, it refers to how the allergy test solution is applied.
  • House Dust Mite (HDM): Tiny insects that commonly live in house dust and can cause allergic reactions in some people.
  • Allergic Rhinitis: An allergic reaction affecting the nose, often causing sneezing, runny nose, and congestion.
  • Rhinoconjunctivitis: A combination of rhinitis (nasal symptoms) and conjunctivitis (eye symptoms) often caused by allergies.
  • Immunotherapy: A treatment that involves exposing the body to small amounts of an allergen to build tolerance over time.

References

  1. http://clinicaltrials.eu/trial/study-on-the-effectiveness-of-purethal-mites-for-adults-with-moderate-to-severe-allergic-rhinitis-or-rhinoconjunctivitis-due-to-house-dust-mite-allergy/