Rare diseases
Investigational molecules
Locations
A plain-language summary of the goals, design and what participants do
This clinical trial is focused on dental procedures that require local anesthesia. The study is investigating the effectiveness of two different anesthetic solutions. One solution is a combination of lidocaine and prilocaine, while the other contains only lidocaine. These medications are used to numb the area in the mouth where dental work is being performed, helping to reduce pain during the procedure.
The purpose of the study is to compare how well these two anesthetic solutions work in people who have a specific genetic trait known as the MC1R mutation. This mutation is often associated with red hair. Participants in the study will receive either the lidocaine-prilocaine combination or the lidocaine alone, and the effectiveness of the anesthesia will be assessed during their dental treatment.
Throughout the study, participants will undergo dental procedures where the anesthetic solutions will be used. The study will measure how well the anesthesia works by checking if the participants feel any sensation in the treated area. The study will also gather feedback from participants about their experience with the anesthesia. This research aims to provide valuable information on the best anesthetic options for dental procedures in individuals with the MC1R mutation.
The trial runs in 6 steps – from screening to follow-up. Each step says what happens and what the team monitors.
3 criteria
1 criterion
Tell us about your condition – we search every trial in Europe and connect you with the right site.
We usually reply within a few days
Where you can join this trial
Countries are shaded by recruitment status. Click a recruiting country to ask about joining there.
Not recruitingJoining a clinical trial can seem overwhelming. We guide you step by step, so you know exactly what to expect and how we support you through the process.
is a mixture of two local anesthetics used to numb a specific area of the body. In this clinical trial, it is being tested to see how well it can reduce pain during dental procedures for people with a specific genetic mutation. The combination is applied to the gums or other areas in the mouth to help prevent pain during dental work.
is a local anesthetic that is commonly used to numb tissues in a specific area. In this trial, it is used alone to see how effective it is at reducing pain during dental procedures. It works by blocking nerve signals in your body, which helps to prevent pain during dental treatments.
This medication is administered as a topical cream applied directly to the skin or gums to numb the area before dental procedures. It is currently being studied in clinical trials to assess its effectiveness compared to lidocaine alone, particularly in individuals with a specific genetic mutation. The main use of this combination is to provide local anesthesia, helping to prevent pain during dental work. At the molecular level, both lidocaine and prilocaine work by blocking sodium channels in nerve cells, which stops pain signals from being sent to the brain. This combination falls under the category of local anesthetics.
Lidocaine is a local anesthetic that is typically applied as a gel or injection to numb specific areas of the body, such as the gums during dental procedures. It is well-established in medical practice and literature as an effective means of preventing pain during minor surgeries and dental work. The primary use of lidocaine is to provide local anesthesia, ensuring that patients do not feel pain in the treated area. It works by blocking sodium channels in nerve cells, which prevents the transmission of pain signals to the brain. Lidocaine is classified as a local anesthetic.
Other trials in this disease – keep exploring while you decide
Denmark
Italy
SpainSpain
The NetherlandsDenmarksourced from the EU Clinical Trials Register and site verification
Want to learn more about this trial or check if you can participate?
Tell us about your condition – we search every trial in Europe and connect you with the right site.
