You must be between 18 and 65 years old to participate in this study

You need to have completed the previous treatment period of Study KAR-012 (through Visit 8)

You must be taking an approved antipsychotic medication from the previous KAR-012 study

You must be able to understand and sign the informed consent form

Your living situation must be considered stable

You need to have a reliable person who can assist with study activities

This support person may complete some assessments by phone, except in Bulgaria where in-person presence may be required

You will receive KarXT capsules to take by mouth

You must continue taking your current antipsychotic medication at the same dose throughout the study

The study will evaluate how safe and well-tolerated KarXT is when taken alongside your current medication

If you or your partner can become pregnant, you must use at least one highly effective method of birth control during the study

Birth control must continue for at least 30 days after the last dose of study medication

Male participants cannot donate sperm for 30 days after the final dose

The study is expected to run from March 2022 to April 2026

During this time, you will be monitored for any side effects that may occur while taking the medication

The study will track both mild and serious side effects, as well as any effects that might lead to stopping the medication