Karuna Therapeutics Inc.

Schizophrenia

Clinical research in schizophrenia focuses on persistent symptom control, with attention to positive and negative symptoms and the management of inadequately controlled disease.

  • Adjunctive treatment for schizophrenia
  • PANSS-based symptom assessment
  • Long-term safety and tolerability

The therapeutic emphasis includes ongoing evaluation of symptom burden in adults living with chronic psychotic illness.

Psychosis associated with Alzheimer’s disease

Research in psychosis associated with Alzheimer’s disease addresses neuropsychiatric symptoms such as hallucinations and delusions in the context of Alzheimer’s disease.

  • Neuropsychiatric symptoms
  • Hallucinations and delusions
  • Alzheimer’s disease-related psychosis

Clinical interest extends to both symptom improvement and longer-term treatment tolerability in this neurodegenerative setting.

Long-term psychiatric safety

Several studies concentrate on extended treatment exposure, with a focus on safety, tolerability, and sustained use in psychiatric disorders.

  • Extended treatment safety
  • Tolerability over time
  • Maintenance of clinical benefit

This area reflects continued monitoring of treatment experience in both schizophrenia and Alzheimer’s disease-related psychosis.

Neuropsychiatric symptom management

The sponsor’s research activity is centered on disorders involving psychosis and broader neuropsychiatric symptom domains, with particular attention to behavioral disturbances and perceptual abnormalities.

  • Psychosis treatment
  • Behavioral symptoms in Alzheimer’s disease
  • Clinical efficacy in psychiatric illness

These studies align with therapeutic development in central nervous system disorders affecting cognition, perception, and behavior.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study on Long-Term Safety of KarXT (Trospium Chloride, Xanomeline Tartrate) for Patients with Alzheimer’s-Related Psychosis

    Recruiting

    3 1 1
    Investigated diseases:
    Belgium Bulgaria Croatia Czechia France Germany +8
  • Long-term safety study of trospium chloride and xanomeline tartrate combination (KarXT) in patients with inadequately controlled schizophrenia symptoms

    Not recruiting

    3 1 1
    Investigated diseases:
    Bulgaria
  • Study on the Effectiveness and Safety of KarXT for Treating Psychosis in Patients with Alzheimer’s Disease

    Not recruiting

    3 1
    Investigated diseases:
    Belgium Greece Hungary Poland
  • Study of KarXT (trospium chloride and xanomeline tartrate) in patients with inadequately controlled schizophrenia symptoms

    Not recruiting

    3 1
    Investigated diseases:
    Bulgaria