This clinical trial is focused on studying the effectiveness of two solutions used in liver transplantation. The solutions being compared are called Custodiol-N and Custodiol. These solutions are used to preserve organs, which means they help keep the liver healthy and functional until it can be transplanted into a patient. Custodiol-N contains a mix of substances like alanine, arginine, deferoxamine, and others, while Custodiol includes ingredients such as mannitol, histidine, and magnesium chloride hexahydrate.
The purpose of this study is to see how well these solutions work in preserving the liver during transplantation. Participants in the study will receive either Custodiol-N or Custodiol. The study will monitor the health of the liver after transplantation by measuring certain markers in the blood over a period of seven days. These markers include GPT (a liver enzyme), LDH (an enzyme that can indicate tissue damage), and other factors like bilirubin and INR (a measure of blood clotting).
Throughout the study, researchers will also look at other aspects of liver function and health, such as the occurrence of cholestasis (a condition where bile cannot flow from the liver to the duodenum), therapy for cholangitis (inflammation of the bile duct system), and any episodes of biliary leakage or strictures. The study aims to provide valuable information on which solution might be more effective in supporting liver health during and after transplantation.
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