Irinotecan
A chemotherapy medication used to treat various types of cancer. In this trial, it is being tested in combination with other medications for treating rhabdomyosarcoma.

Ifosfamide
A chemotherapy medication that works by stopping cancer cells from dividing and growing. It is used as part of combination therapy for treating rhabdomyosarcoma.

Vincristine
A chemotherapy medication that prevents cancer cells from dividing. It is commonly used in combination with other medications to treat various types of cancer, including rhabdomyosarcoma.

Actinomycin D
A chemotherapy medication that works by interfering with cancer cell DNA. It is used as part of combination therapy for treating rhabdomyosarcoma.

Vinorelbine
A chemotherapy medication that works by stopping cancer cells from separating into new cells. In this trial, it is being tested as part of maintenance therapy.

Cyclophosphamide
A chemotherapy medication that works by slowing or stopping cell growth. In this trial, it is being used as part of maintenance therapy and can be given orally.

Regorafenib
A targeted therapy medication that works by blocking several proteins that signal cancer cells to grow. It is being tested in combination with other medications for treating relapsed rhabdomyosarcoma.

Temozolomide
A chemotherapy medication that works by stopping cancer cells from making new DNA. In this trial, it is being used as part of combination therapy for treating relapsed rhabdomyosarcoma.

Rhabdomyosarcoma – A rare type of cancer that develops in soft tissue, specifically in muscle cells that are in the process of developing. It most commonly occurs in children and teens, forming in muscles that are attached to bones. The disease can start in various parts of the body, including the head and neck area, arms, legs, trunk, or in internal organs. As the tumor grows, it can cause swelling, pain, or changes in the affected area. The cancer cells can spread to other parts of the body through the blood or lymph system if not addressed.