Atorvastatin is a medication that belongs to a group of drugs called statins. It is used to lower cholesterol levels in the blood. By reducing cholesterol, atorvastatin helps prevent heart disease and stroke. In this clinical trial, researchers are studying how atorvastatin affects the way the body processes cholesterol and bile acids, which are substances that help digest fats.

Evolocumab is a medication known as a PCSK9 inhibitor. It works by helping the liver remove more cholesterol from the blood, which can lower the risk of heart disease. In this study, evolocumab is being examined to understand its impact on cholesterol and bile acid metabolism in the body. This research aims to provide insights into how evolocumab can help manage cholesterol levels effectively.

Healthy volunteers – This term refers to individuals who do not have any known medical conditions or diseases. They are often used in clinical trials to provide baseline data for comparison with individuals who have specific health conditions. Healthy volunteers typically have normal physiological functions and are not experiencing symptoms of illness. Their participation helps researchers understand the effects of new treatments or interventions in a controlled environment. The progression of health in these individuals is generally stable, as they do not exhibit disease-related changes. They serve as a control group to help identify the effects of the treatment being studied.