Study of drug combinations including cisplatin, carboplatin, doxorubicin, fluorouracil, vincristine, etoposide, irinotecan, gemcitabine, oxaliplatin and sorafenib for children with hepatoblastoma or hepatocellular carcinoma

Based on the clinical trial data provided, here are the medication descriptions: Cisplatin - An intravenously administered platinum-based chemotherapy drug that works by binding to DNA and interfering with cell division. It belongs to the alkylating agents class and is primarily used in the treatment of hepatoblastoma and hepatocellular carcinoma, particularly in pediatric patients. The medication acts by creating cross-links in DNA that trigger apoptosis in cancer cells. Carboplatin - A platinum-based chemotherapy medication given through intravenous infusion that causes less severe side effects than cisplatin while maintaining similar anti-cancer properties. It belongs to the platinum-containing compounds class and works by interfering with DNA replication in cancer cells, making it effective in treating liver cancers in children. Doxorubicin - An intravenous chemotherapy medication from the anthracycline class that works by blocking DNA and RNA synthesis in cancer cells. It is commonly used in combination therapy for hepatoblastoma and hepatocellular carcinoma, interfering with the growth and spread of cancer cells through multiple mechanisms. Vincristine - A plant-derived chemotherapy medication administered intravenously that belongs to the vinca alkaloid class. It works by preventing cancer cells from dividing by disrupting microtubules during cell division, and is often used as part of combination therapy protocols for liver cancers. Sorafenib - An oral targeted therapy medication that belongs to the kinase inhibitor class. It works by blocking specific proteins that promote cancer cell growth and blood vessel formation, used specifically in advanced hepatocellular carcinoma to slow tumor growth and spread. Irinotecan - An intravenously administered chemotherapy drug that belongs to the topoisomerase inhibitor class. It works by preventing DNA repair in cancer cells, leading to cell death, and is used as part of combination therapy protocols in resistant or advanced liver cancers. Gemcitabine - An intravenous chemotherapy medication belonging to the antimetabolite class that works by replacing one of the building blocks of DNA, thereby preventing cancer cells from growing. It is used in combination with other drugs for treating advanced liver cancers. Oxaliplatin - An intravenously administered platinum-based chemotherapy drug that forms cross-links in DNA, preventing cancer cell division. It belongs to the platinum compounds class and is used in combination therapy for advanced liver cancers, particularly when other treatments have not been effective. 5-fluorouracil - An intravenously administered chemotherapy drug from the antimetabolite class that works by interfering with DNA and RNA synthesis in cancer cells. It is commonly used in combination therapy protocols for liver cancers, preventing cancer cell growth and division. Etoposide - An intravenous chemotherapy medication that belongs to the topoisomerase inhibitor class. It works by damaging DNA in cancer cells to prevent their division and growth, and is used as part of combination therapy protocols in treating resistant liver cancers.