This clinical trial is focused on studying the treatment of Enterococcus faecalis infective endocarditis, a serious infection of the heart’s inner lining caused by the bacteria Enterococcus faecalis. The study will compare two methods of administering antibiotics: continuous infusion and intermittent infusion. The antibiotics being tested are ampicillin and ceftriaxone. Ampicillin is a type of penicillin antibiotic, while ceftriaxone is a cephalosporin antibiotic. Both are commonly used to treat bacterial infections.

The purpose of the study is to determine if continuous infusion of these antibiotics is as effective as intermittent infusion in treating the infection. Participants in the study will receive either the continuous or intermittent infusion of the antibiotics. The study will monitor the frequency of disease recurrence, which means checking if the infection comes back after treatment. The study will also look at other factors, such as the need for changes in antibiotic treatment, unplanned surgeries, and any side effects related to the medication.

The study will last for a period of up to 42 days of treatment, with follow-up assessments to check for any recurrence of the infection or other health issues. Participants will be monitored for up to one year after completing the antibiotic treatment to ensure the infection does not return and to assess overall health outcomes. The study aims to provide valuable information on the best way to administer these antibiotics for treating Enterococcus faecalis infective endocarditis.