Zenagamtide is a medication administered through a small needle under the skin. In this study, it is being tested to see how well it helps people who are overweight or have obesity to lose body weight and to reduce pain caused by osteoarthritis in the knee.

Obesity – This is a condition where an individual has accumulated an excessive amount of body fat. It is often characterized by a high body mass index and increased body fat percentage. Over time, the condition can lead to various metabolic changes in the body. It typically develops due to an imbalance between energy intake from food and the energy used by the body.

Osteoarthritis – This is a common joint condition that occurs when the protective tissue at the ends of the bones wears down over time. While it can affect many joints, it frequently impacts the knees. As the cartilage thins, the bones may rub against each other, causing discomfort and stiffness. The condition often progresses gradually, leading to changes in joint structure and movement.