Study of the effects of stopping elranatamab and teclistamab treatment in patients with multiple myeloma who have had a significant response to therapy.

2 1 1 1

What is this study about?

This study is being conducted to evaluate how long people can stay in remission after stopping a specific type of treatment for Multiple Myeloma, which is a type of blood cancer that affects plasma cells in the bone marrow. The study focuses on patients who have had a significant reduction in their M-spike, a measurement of the abnormal protein produced by cancer cells in the blood. The medications being studied are elranatamab and teclistamab, which are known as BCMA-CD3 bispecific antibodies. These are specialized drugs designed to help the immune system find and attack the cancer cells.

The purpose of this study is to determine how long the disease remains inactive and how much time can pass without treatment after the medications are stopped. During the study, patients will receive the medication through a subcutaneous injection, which is a shot given into the fatty tissue just under the skin. Participants will be monitored to see if the cancer returns or if the response to the treatment lasts over time. Researchers will also look at how the medications affect overall survival and the frequency of side effects, such as infections, both during and after the treatment period.

Who Can Join the Study?

  • You must provide written consent, which means you sign a document agreeing to take part in the study.
  • You must have a diagnosis of multiple myeloma, which is a type of cancer that affects the plasma cells in your blood.
  • You must be currently receiving BCMA-CD3 bispecific antibody therapy, a specific type of immune system treatment.
  • You must have achieved a biochemical complete response, meaning that tests show your cancer is currently undetectable or very low.
  • Your M-spike, which is a measurement of a specific protein produced by the cancer, must be unmeasurable or at a very low level.
  • Your free light chains, which are small proteins produced by plasma cells, must be within a normal range or unmeasurable.
  • You must have had measurable disease before starting this specific treatment, meaning your cancer levels were high enough to be clearly detected by tests.
  • You must have your baseline data from your initial diagnosis, which refers to your original medical test results.
  • You must have records of your earlier treatments for multiple myeloma.
  • You must be 18 years of age or older.

Who Cannot Join the Study?

  • You are unable to follow the specific rules and schedules for monitoring your disease as required by the study plan.
  • You have a severe concomitant disease, which means a serious other medical condition, that is expected to limit your life expectancy to less than 6 months.
  • You are unable to provide informed consent, which is the formal legal agreement to participate in a study after understanding all the risks and benefits.
  • Your multiple myeloma is of the IgD or IgE type, which are specific and rare versions of this blood cancer defined by the type of proteins found in your blood.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

No sites found in this category

Other Sites

Site Name City Country Status
Region Oestergoetland Linkoping Sweden
Region Oerebro Laen Orebro Sweden
Region Vaesterbotten Umea Sweden
Region Skane Helsingborg Hospital Helsingborg Sweden
Region Dalarna Falun Sweden
Soedra Aelvsborg Hospital Vaestra Goetalandsregionen Boras Sweden
NU Hospital Group-Vaestra Goetalandsregionen Trollhattan Sweden
Region Halland Varberg Sweden
Region Skane Skanes Universitetssjukhus Lund Sweden
Karolinska University Hospital Solna Sweden
Region Joenkoepings Laen Jönköping Sweden
Queen Silvia Childrens Hospital – Sahlgrenska University Hospital – Vaestra Goetalandsregionen Gothenburg Sweden
Uhttcqg Uwonkfwxwr Hbfsbfmj Uppsala Sweden

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Sweden Sweden
Recruiting
01.03.2026

Trial locations

Investigated drugs:

Elranatamab is a type of immunotherapy given as a subcutaneous injection. It is designed to help the body’s immune system recognize and attack certain cancer cells in patients with multiple myeloma.

Teclistamab is a type of immunotherapy given as a subcutaneous injection. It works by linking the body’s own immune cells to the cancer cells to help destroy them in patients with multiple myeloma.

Multiple myeloma – This is a type of cancer that develops in the plasma cells, which are a type of white blood cell. These abnormal cells accumulate in the bone marrow and interfere with the production of healthy blood cells. As the disease progresses, the plasma cells produce large amounts of an abnormal protein. This accumulation can lead to damage in various parts of the body, particularly the bones. The condition often evolves through stages of increasing cell activity within the marrow.

Trial ID:
2025-524022-18-00
Protocol code:
SWE-DISCO-MM1
Trial Phase:
Therapeutic exploratory (Phase II)

Other Trials to Consider

  • A Phase 3 Randomized Study of mRNA‑4157 plus Pembrolizumab as Adjuvant Therapy in Patients with Completely Resected Stage I Non‑Small Cell Lung Cancer

    Recruiting

    3 1
    Investigated drugs:
    France Germany Greece Hungary Italy The Netherlands +2
  • Study of MK-1084 plus durvalumab versus placebo plus durvalumab in patients with locally advanced KRAS G12C‑mutant non‑small cell lung cancer after chemoradiotherapy

    Recruiting

    3 1 1
    Investigated diseases:
    Investigated drugs:
    France Germany Greece Italy The Netherlands Poland +1