Nivolumab is a type of medication known as an immune checkpoint inhibitor. It works by helping your immune system recognize and attack cancer cells. In this trial, nivolumab is given as a shot under the skin, which is different from the usual way it is given through a vein. This study is looking at how the body absorbs and processes nivolumab when it is given in this new way.

rHuPH20 is a substance that helps medications spread more easily under the skin. It is used in this trial to see if it can help nivolumab work better when given as a shot under the skin. By combining rHuPH20 with nivolumab, researchers hope to improve the delivery and effectiveness of the cancer treatment.

Lung Cancer – Lung cancer is a disease characterized by the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not develop into healthy lung tissue and can form tumors. As the disease progresses, these tumors can interfere with the lung’s ability to provide oxygen to the bloodstream. The cancer can spread to other parts of the body through the lymphatic system or bloodstream. Symptoms may include persistent cough, chest pain, and shortness of breath. The progression can vary depending on the type and stage of the cancer.

Kidney Cancer – Kidney cancer begins in the kidneys, which are two bean-shaped organs located behind the abdominal organs. The most common type is renal cell carcinoma, which starts in the lining of small tubes in the kidney. As the disease progresses, it can lead to the formation of a mass or tumor in the kidney. This can affect kidney function and potentially spread to other parts of the body. Symptoms may include blood in the urine, back pain, and weight loss. The progression can vary based on the size and spread of the tumor.

Melanoma – Melanoma is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. It often appears as a new mole or a change in an existing mole. As melanoma progresses, it can invade deeper layers of the skin and spread to other parts of the body. This spread can occur through the lymphatic system or bloodstream. Symptoms may include changes in the size, shape, or color of a mole. The progression can vary depending on the depth of skin invasion and spread to other organs.

Liver Cancer – Liver cancer is a disease in which malignant cells form in the tissues of the liver. The most common type is hepatocellular carcinoma, which starts in the main type of liver cell. As the disease progresses, it can lead to the formation of tumors that impair liver function. These tumors can also spread to other parts of the body. Symptoms may include weight loss, loss of appetite, and jaundice. The progression can vary based on the size and number of tumors.

Colorectal Cancer – Colorectal cancer begins in the colon or rectum, which are parts of the large intestine. It typically starts as a growth called a polyp on the inner lining of the colon or rectum. As the disease progresses, these polyps can become cancerous and invade deeper layers of the colon or rectum. The cancer can spread to other parts of the body through the lymphatic system or bloodstream. Symptoms may include changes in bowel habits, blood in the stool, and abdominal discomfort. The progression can vary depending on the size and spread of the cancer.

Bladder Cancer – Bladder cancer is a disease in which malignant cells form in the tissues of the bladder. The most common type is transitional cell carcinoma, which begins in the cells lining the bladder. As the disease progresses, it can lead to the formation of tumors that affect bladder function. These tumors can also spread to other parts of the body. Symptoms may include blood in the urine, frequent urination, and pelvic pain. The progression can vary based on the size and spread of the tumors.