This study involves patients who are having scheduled surgery to remove part of the colon or rectum due to colorectal cancer using a laparoscopic approach, which means the surgery is done through small incisions using a camera and specialized instruments. The study will use two different pain relief medications during and after the surgery: lidocaine, which will be given through a vein during the operation, and ropivacaine, which will be injected into the areas where the surgical instruments are inserted. In addition to these two main medications, patients may receive other medications commonly used during and after surgery to manage pain and support recovery, including nefopam, dexamethasone, paracetamol, sufentanil, parecoxib, celecoxib, morphine sulfate, propofol, and ketamine.
The purpose of this study is to evaluate how well the combination of intravenous lidocaine and ropivacaine infiltration at the surgical sites helps patients recover after their colorectal surgery. Recovery will be measured using a questionnaire called the QOR-15, which assesses how well patients are doing twenty-four hours after their operation. The study will also examine whether these medications reach levels in the blood that could cause unwanted effects, and will look for any signs of medication-related problems in the first two hours after surgery. Pain levels will be measured at different times using a numbering system where patients rate their pain, both when resting and when moving.
During the study, patients will be monitored for various aspects of their recovery over a period that extends to three months after surgery. This includes tracking how much pain medication they need, when their digestive system starts working normally again, whether they experience any unusual sensations around the surgical area, and whether they develop any nerve-related pain. The study will also record any medical or surgical complications that occur, whether patients are able to start chemotherapy if needed within two months after surgery, how long patients stay in the hospital, and how satisfied patients are with their care when they leave the hospital. Blood samples will be taken to measure the levels of lidocaine and ropivacaine in the bloodstream.



France