This study is looking at people with infectious disease who need treatment with antibiotics. The treatment being used is a combination of two medicines called piperacillin and tazobactam. These medicines are normally given through a vein, which means a needle is placed into a vein and the medicine drips slowly into the bloodstream. This study wants to test if giving these medicines under the skin, which means injecting them into the tissue just beneath the skin surface, works just as well as giving them through a vein. The study will include people who have serious infections such as severe lung infection, fever in patients with low white blood cell counts that may be caused by bacteria, or other serious bacterial infections.
The purpose of the study is to compare how the body processes these medicines when they are given under the skin compared to when they are given through a vein. During the study, patients will receive either the medicine under the skin or through a vein. Blood samples will be collected to measure the amount of medicine in the blood over time. This helps researchers understand if the medicine reaches the same levels in the body with both methods of giving it. The treatment period will last for up to ten days, and doctors will check how well the infection is responding to the treatment.
The study will also look at whether the medicine levels in the blood stay high enough to fight the infection effectively. Doctors will measure if the signs and symptoms of infection improve or go away without needing additional antibiotics. They will also check if the bacteria causing the infection are eliminated. Any side effects or unwanted reactions that occur during treatment and up to one day after treatment ends will be recorded. This information will help determine if giving these antibiotics under the skin is a safe and effective alternative to giving them through a vein.
Italy 
