This study focuses on patients undergoing an open hepatectomy, which is a major surgical procedure to remove a portion of the liver. The research aims to compare the effects of an infusion of lidocaine hydrochloride with a placebo on side effects caused by opioids, which are strong pain medications, following the surgery. Potential complications being monitored include postoperative nausea and vomiting, hypoxemia, which is a condition where there is not enough oxygen in the blood, and postoperative ileus, a temporary lack of normal muscle contractions in the intestines that prevents the passage of food or gas.

Participants in the study will receive either lidocaine hydrochloride or sodium chloride through an intravenous infusion, meaning the substance is delivered directly into a vein. The study period covers the time around the surgery and the first 48 hours after the breathing tube is removed. Various factors such as pain levels, the amount of pain medication used, the length of time spent in the hospital, and the risk of other issues like pneumonia or acute kidney insufficiency will be observed during the recovery process.