This clinical trial focuses on patients with traumatic brain injury, a condition where the brain is damaged due to external force or trauma. The study aims to evaluate whether giving a continuous infusion of hypertonic saline solution through a vein early in treatment can help improve survival and the ability to perform daily activities in patients who are at high risk of increased pressure inside the skull.
The study will use two treatments: sodium chloride solution and mannitol solution, both given through an intravenous line. These medications help control the pressure inside the brain after injury. Patients will receive treatment for up to 7 days while being monitored in an intensive care unit.
The study will track how well patients recover over time, particularly focusing on their survival after 3 months and their ability to perform daily activities independently after 6 months. Doctors will monitor various aspects of patient health, including salt levels in the blood and kidney function, to ensure the treatment is safe. The evaluation of how well patients recover will be done by medical professionals who do not know which treatment the patient received.
France 