Centre Hospitalier Universitaire De Nantes

Hematologic Malignancies and Cellular Therapy

Acute myeloid leukemia, acute leukemia, multiple myeloma, and mantle cell lymphoma are central areas of interest, alongside transplant-linked care for high-risk blood cancers. The portfolio also includes studies in minimal residual disease assessment and allogeneic stem cell transplantation.

  • Acute myeloid leukemia
  • Multiple myeloma
  • Mantle cell lymphoma
  • Allogeneic stem cell transplantation
  • Minimal residual disease

Research activity extends to immune-based and transplant-adjacent approaches in patients with relapsed, refractory, or high-risk hematological disease.

Transplantation and Immunosuppression

The sponsor is active in kidney transplant, heart transplant, pancreatic transplant, and management of graft dysfunction and chronic renal failure. Work also covers immunosuppressive strategies and prevention of transplant-related complications.

  • Kidney transplant
  • Heart transplant
  • Pancreatic transplant
  • Graft dysfunction
  • Immunosuppression

Clinical research includes renal and cardiac graft preservation, rejection-related care, and post-transplant immune modulation.

Infectious Disease and Perioperative Care

Studies address hospital-acquired pneumonia, community-acquired pneumonia, MRSA, and staphylococcal endocarditis, with additional interest in perioperative infection control and antimicrobial selection. Surgical settings include cardiac, orthopedic, and transplant-related care.

  • Hospital-acquired pneumonia
  • Community-acquired pneumonia
  • MRSA
  • Staphylococcal endocarditis
  • Perioperative infection prevention

The research landscape also includes microbial decolonization, antifungal prophylaxis, and infection management in hospitalized adults.

Respiratory, Critical Care, and Emergency Medicine

Another major focus is severe asthma, traumatic brain injury, severe burns, and acute metabolic or respiratory instability requiring hospital-based intervention. The sponsor also supports work in hyperkalemia and urgent airway management.

  • Severe asthma
  • Traumatic brain injury
  • Severe burns
  • Hyperkalemia
  • Rapid sequence induction

These studies reflect interest in acute care pathways, critical illness, and treatment strategies for unstable patients in emergency and intensive care settings.

Autoimmune, Gastrointestinal, Pain, and Surgical Conditions

Research includes multiple sclerosis, atopic dermatitis, ulcerative colitis with recurrent pouchitis, severe primary dysmenorrhea, and postoperative pain syndromes. Surgical topics also include cardiac surgery, orthopedic trauma surgery, and shoulder arthroplasty.

  • Multiple sclerosis
  • Atopic dermatitis
  • Ulcerative colitis
  • Severe primary dysmenorrhea
  • Postoperative pain

Additional activity covers functional and behavioral conditions such as gambling disorder, as well as surgical infection prevention and pain control in complex procedures.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study of Clindamycin Use During Heart Surgery with Extracorporeal Circulation to Prevent Surgical Site Infections

    Recruiting

    2 1 1 1
    Investigated drugs:
    France
  • Study of hypertonic saline solution and mannitol to improve recovery in patients with traumatic brain injury and high risk of intracranial hypertension

    Recruiting

    3 1 1 1
    Investigated drugs:
    France
  • Study of Gallium (68Ga) edotreotide, Fluorocholine (18F) and Fludeoxyglucose (18F) PET imaging for detection and staging of liver cancer and gastro-entero-pancreatic tumors

    Recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    France
  • Comparing rifampin-free treatment versus rifampin in adults with staphylococcal prosthetic valve endocarditis

    Recruiting

    3 1 1 1
    France
  • Evaluation of Botulinum Toxin Injections for Women with Severe Primary Dysmenorrhea Unresponsive to First-Line Treatments

    Recruiting

    3 1 1
    France
  • Study of dexamethasone effectiveness in reducing complications and mortality in patients with severe burns

    Recruiting

    3 1 1
    Investigated diseases:
    France