Everolimus (also known as a rapamycin analog) is a medication that helps regulate cell growth and survival. It belongs to a class of drugs called mTOR inhibitors. In this trial, it is being studied for its potential effects on bone formation in postmenopausal women.

Resistance Training is a form of physical exercise therapy that involves working against a force or weight to build strength and muscle mass. In this trial, it is being used to study its effects on bone formation and strength in postmenopausal women.

The combination therapy includes both everolimus and resistance training together, which is being studied to determine if using both treatments simultaneously could provide better results for bone formation than using either treatment alone.

Osteoporosis – A condition where bones become weak and brittle due to decreased bone density and deteriorating bone structure. The body loses too much bone mass or makes too little new bone tissue, leading to an increased risk of fractures. The condition develops slowly over several years, often without noticeable symptoms in the early stages. Bone loss occurs when the creation of new bone doesn’t keep up with the removal of old bone. The condition particularly affects postmenopausal women due to decreased estrogen levels.

Sarcopenia – A progressive loss of skeletal muscle mass and strength that occurs with advancing age. The condition involves the gradual loss of muscle tissue and strength that can affect daily activities. Muscle mass naturally begins to decrease between 3-8% per decade after the age of 30, with a more rapid decline after age 60. The loss of muscle mass is typically accompanied by a decrease in muscle quality and function.