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Soya Oil, Purified

This article explores the use of Soya Oil, Purified, a key ingredient in Intralipide 20%, in clinical trials focusing on postoperative pain management in children. The study aims to investigate the effectiveness of locoregional analgesia in preventing persistent postoperative pain after orthopedic trauma surgery in pediatric patients.

Table of Contents

What is Soya Oil, Purified?

Soya Oil, Purified is a medical product derived from soybeans. It is also known as Purified Soya-Bean Oil.[1] This substance is used in medical settings as part of a treatment called fat emulsion, which is a way to provide nutrition to patients who cannot eat normally.

Medical Uses

Soya Oil, Purified is primarily used in medical settings for nutritional support. It is a component of intravenous nutrition, also known as parenteral nutrition. This type of nutrition is used when a patient cannot eat by mouth or when the digestive system is not functioning properly.[1]

Some specific situations where Soya Oil, Purified might be used include:

  • After surgery, when a patient cannot eat normally
  • In patients with certain digestive system disorders
  • In critically ill patients who need additional nutritional support

How is it Administered?

Soya Oil, Purified is administered through intravenous infusion. This means it is given directly into the bloodstream through a vein.[1] It is not a medication that you would take by mouth or apply to your skin.

The product used in medical settings is called INTRALIPIDE 20 POUR CENT, émulsion pour perfusion, which translates to “Intralipid 20 Percent, emulsion for infusion” in English. This is a sterile fat emulsion that contains purified soya oil along with other ingredients to make it safe for intravenous use.

Dosage Information

The dosage of Soya Oil, Purified is carefully calculated by healthcare professionals based on a patient’s individual needs. According to the information provided, the maximum daily dose is 3 milliliters per kilogram of body weight.[1]

It’s important to note that this medication is typically administered in a hospital or clinical setting under close medical supervision. Patients do not typically administer this medication to themselves at home.

Precautions and Considerations

While Soya Oil, Purified is an important medical product, there are some considerations to keep in mind:

  • Allergies: If you have a known allergy to soybeans or any other components of the emulsion, you should inform your healthcare provider.
  • Other medical conditions: Your doctor will consider your overall health status and any other medical conditions you have when deciding whether to use this treatment.
  • Monitoring: During the infusion, medical staff will monitor you closely for any adverse reactions.

It’s crucial to provide your healthcare team with a complete medical history and information about any allergies or sensitivities you may have. This will help ensure that the treatment is safe and appropriate for you.

Aspect Details
Study Drug Intralipide 20% (containing Soya Oil, Purified)
Main Objective Evaluate impact of locoregional analgesia on preventing persistent postoperative pain in children
Patient Age Range 5 years to 15 years and 3 months
Maximum Daily Dose 3 milliliters per kilogram
Treatment Duration 1 day
Primary Outcome Measure Pain assessment using NRS at 3 months post-surgery
Key Secondary Outcomes Neuropathic pain, immediate post-op pain, chronic pain persistence, nausea/vomiting incidence, ICU monitoring time, opioid consumption
Study Design Randomized trial comparing locoregional analgesia + general anesthesia vs. general anesthesia alone

FAQ

  • What is the main purpose of using Soya Oil, Purified in this clinical trial? Soya Oil, Purified is a component of Intralipide 20%, which is being used as part of a fat emulsion for intravenous infusion. The main purpose of the trial is to study the impact of locoregional analgesia, which may include this product, in preventing persistent postoperative pain in children after orthopedic trauma surgery.
  • What age group of children is included in this study? The study includes children aged 5 years or older but younger than 15 years and 3 months.
  • What is the maximum daily dose of Intralipide 20% used in the trial? The maximum daily dose of Intralipide 20% used in the trial is 3 milliliters per kilogram of body weight.
  • How long does the treatment period last? The maximum treatment period is 1 day, as indicated by the trial information.
  • What are the main outcomes being measured in this study? The primary outcome is the measurement of pain using a Numerical Rating Scale (NRS) 3 months after pediatric orthopedic trauma surgery. Secondary outcomes include assessing neuropathic pain, immediate post-operative pain, persistence of chronic post-surgical pain, incidence of postoperative nausea and vomiting, monitoring times in the ICU, and opioid consumption during hospitalization.

Ongoing Clinical Trials on Soya Oil, Purified

  • Study on Preventing Persistent Postoperative Pain in Children Using Mepivacaine Hydrochloride and Drug Combination

    Recruiting

    3 1 1 1
    Investigated drugs:
    France

Glossary

  • Locoregional Analgesia: A pain management technique that involves injecting medication near nerves or in specific areas of the body to numb pain in a targeted region.
  • Persistent Postoperative Pain: Pain that continues for an extended period after surgery, beyond the expected healing time.
  • Orthopedic Trauma Surgery: Surgical procedures performed to treat injuries to the bones, joints, and soft tissues of the body.
  • Neuropathic Pain: Pain caused by damage or disease affecting the nervous system, often described as burning, shooting, or electric-like sensations.
  • Numerical Rating Scale (NRS): A pain assessment tool where patients rate their pain intensity on a scale from 0 (no pain) to 10 (worst pain imaginable).
  • Post-Interventional Monitoring Room: A specialized area where patients are closely observed immediately after surgery or medical procedures.
  • Opiates: A class of pain-relieving medications derived from or similar to substances found in opium.
  • Intravenous Infusion: A method of delivering fluids or medications directly into a vein using a needle or catheter.
  • Fat Emulsion: A mixture of fats and water that can be safely administered intravenously, often used for nutrition or as a component in medication delivery.
  • DN4 Questionnaire: A screening tool used to identify neuropathic pain components in patients.

References

  1. http://clinicaltrials.eu/trial/study-on-preventing-persistent-postoperative-pain-in-children-using-mepivacaine-hydrochloride-and-drug-combination/