This study is looking at abdominal aortic aneurysm, which is a bulging or swelling in the main blood vessel that carries blood from the heart down through the abdomen. The study involves patients who are planned to have a procedure called fenestrated endovascular aneurysm repair, which is a way to fix this bulging blood vessel from the inside using special tubes and devices. During this procedure, doctors need to see the blood vessels clearly, and they typically use iodine contrast media, which are special liquids that help make blood vessels visible on imaging scans. The study will use different types of iodine contrast products including iohexol, iomeprol, and iodixanol, which are all injected into the blood vessels to help with imaging.
The purpose of the study is to find out if using less iodine contrast during the procedure by using carbon dioxide gas instead when possible can reduce kidney problems after the surgery compared to the usual approach. Kidney problems can sometimes happen after this type of procedure because the contrast material can affect how the kidneys work. The study will compare two different strategies: one that tries to use carbon dioxide for imaging whenever possible to reduce the amount of iodine contrast needed, and one that uses the standard amount of iodine contrast.
During the study, patients will be randomly assigned to receive one of these two imaging strategies during their planned procedure. The doctors will monitor kidney function by checking blood tests and urine output after the surgery to see if there are any signs of kidney injury. Patients will be followed for up to three years after the procedure with regular check-ups, imaging scans, and questionnaires about their quality of life and recovery. The study will also track other important outcomes such as the success of the surgery, any complications that occur, survival rates, and changes in kidney function over time.
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