This study is looking at non-small cell lung cancer, which is a type of cancer that affects the lungs. The study will use a substance called [18F]FAPI-74, which is given as an injection into a vein. This substance is used together with a special scanning method called PET/CT imaging, which creates detailed pictures of the inside of the body. The substance helps doctors see areas where cancer cells might be present because it attaches to a specific protein that is often found in and around cancer tissue.

The purpose of this study is to see if this imaging method can help doctors find out whether the cancer has spread to lymph nodes, which are small bean-shaped organs that are part of the body’s defense system, or to other parts of the body that are far from where the cancer started. The study will look at patients who have not received any treatment yet, as well as patients who have already had surgery, radiation therapy, or other treatments for their lung cancer and might have cancer that has come back.

During the study, patients will receive a single injection of the substance and then have imaging scans taken to see how well the substance shows areas of cancer in the body. Doctors will measure how much of the substance collects in different areas and will compare the scan results with tissue samples taken from suspected cancer areas to confirm whether cancer is present. The study aims to determine if this imaging approach can be useful in understanding where the cancer is located and whether it has spread.