This study focuses on patients with metastatic colorectal cancer who cannot receive intensive therapy. The research compares two different treatment combinations. The first combination includes trifluridine/tipiracil with bevacizumab, while the second combines capecitabine with bevacizumab. Metastatic colorectal cancer occurs when cancer that starts in the colon or rectum spreads to other parts of the body.
The main purpose of this study is to determine if the combination of trifluridine/tipiracil with bevacizumab works better than capecitabine with bevacizumab as a first treatment option. The medications are given in different ways – some are taken as tablets by mouth, while bevacizumab is given through an intravenous line (directly into a vein).
During the study, doctors will monitor how the disease responds to treatment and track any side effects that may occur. They will also evaluate how the treatments affect patients’ overall health and quality of life. The study is “open-label,” which means both doctors and patients know which treatment is being given.



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