Somapacitan is a medication used in this study to help children grow taller. It is given once a week and is being tested to see if it works as well as another medication that is given every day. The study is looking at how well it helps children who are shorter than usual because they were born small, have Turner syndrome, Noonan syndrome, or have no known reason for their short stature.

Norditropin is a medication that is already used to help children grow taller. It is given every day and is being compared to somapacitan in this study. The goal is to see if the once-a-week medication works just as well as this daily treatment in helping children grow.

Short Stature in Children Born Small for Gestational Age (SGA) – This condition occurs when a child is born smaller than the typical size for the number of weeks of pregnancy. These children may experience slower growth rates compared to their peers. Over time, they might not catch up in height, leading to a diagnosis of short stature. The growth pattern can vary, with some children showing improvement in growth velocity during early childhood.

Turner Syndrome – A genetic disorder affecting females, characterized by the partial or complete absence of one of the X chromosomes. This condition often results in short stature, which becomes noticeable by early childhood. Other features may include delayed puberty and certain physical characteristics. Growth hormone therapy is commonly used to help increase height in affected individuals.

Noonan Syndrome – A genetic disorder that can affect various parts of the body, often leading to distinctive facial features, heart defects, and short stature. Children with Noonan syndrome may have a slower growth rate, which becomes apparent in early childhood. The condition can also be associated with developmental delays and other health issues. Growth patterns can vary widely among individuals with this syndrome.

Idiopathic Short Stature (ISS) – This term is used when a child is significantly shorter than average for their age and sex, with no identifiable medical cause. Children with ISS have normal body proportions and no signs of systemic disease. The growth rate is typically slower than average, and the final adult height is often below the expected range. The condition is diagnosed after ruling out other potential causes of short stature.