Aspirin (ASA) is a commonly used medication that helps prevent blood clots. It works by making blood platelets less sticky, which reduces the risk of clots forming in blood vessels and grafts after heart surgery. In this trial, both low-dose and high-dose versions are being studied.

Prasugrel is a medication that works together with aspirin to prevent blood clots. It is more potent than aspirin alone and is often used in patients who have had heart procedures. It helps keep the blood vessels and surgical grafts open after coronary bypass surgery by preventing platelets from sticking together.

Coronary Artery Disease – A condition where the blood vessels supplying the heart become narrowed or blocked due to the buildup of fatty deposits called plaque. This chronic condition develops gradually over time as cholesterol and other substances accumulate in the arterial walls. The narrowing of arteries reduces blood flow to the heart muscle, which can cause chest pain (angina) during physical activity. The disease can affect multiple coronary arteries simultaneously, leading to reduced heart function. As the disease progresses, the arteries become increasingly narrow, potentially affecting daily activities.

Chronic Coronary Syndrome – A stable form of coronary artery disease characterized by predictable episodes of chest discomfort or shortness of breath. The condition typically occurs during physical exertion or emotional stress when the heart needs more oxygen than the narrowed arteries can provide. Between episodes, patients may feel normal and have no symptoms. The pattern of symptoms usually remains stable over time without sudden worsening. This condition represents the stable phase of coronary artery disease where symptoms are relatively predictable and manageable.