This study focuses on patients with locally advanced resectable rectal cancer located in the middle or lower part of the rectum. The research aims to compare two different treatment approaches: using chemotherapy alone versus using chemotherapy followed by combined chemotherapy and radiation therapy before surgery.
The treatment involves several medications given through intravenous infusion, including irinotecan hydrochloride, calcium folinate, fluorouracil, and oxaliplatin. These medications are commonly used to treat various types of cancer and work together to stop or slow down the growth of cancer cells.
During the study, patients will receive treatment over multiple cycles. The effectiveness of the treatment will be monitored for three years after the start of treatment to determine how well it prevents the cancer from returning or spreading. The study will help determine if chemotherapy alone can be as effective as the combination of chemotherapy and radiation therapy in treating this type of rectal cancer.
France 
