This study examines how effectively different antihistamine medications prevent skin reactions caused by histamine. The medications being tested are bilastine 20 mg, ebastine 10 mg, and desloratadine 5 mg, all in dissolving tablet form, compared to placebo. The purpose is to determine how quickly these medications start working to reduce skin reactions.
The medications are designed to treat allergies by blocking the effects of histamine in the body. Each medication is taken by mouth in the form of a tablet that dissolves on the tongue. During the study, participants will receive each of the three medications and placebo at different times, with appropriate breaks between treatments.
The study will measure how well each medication prevents the development of raised, itchy bumps and redness on the skin after histamine exposure. Researchers will monitor participants’ reactions at various time points after taking the medication to understand how quickly each drug starts working, how long the effects last, and how strong the effects are compared to placebo.



Spain