This study focuses on patients experiencing a large ischemic stroke, which is a type of brain attack that occurs when a blood vessel in the brain is blocked by a clot. A specific type of this condition being investigated is a large vessel occlusion stroke, where a major artery in the brain is shut by a blockage. The purpose of the study is to compare two different ways of treating this condition to see which one leads to better physical recovery after three months.

One treatment approach involves thrombectomy, a procedure where doctors use specialized tools to physically remove the clot from the blocked artery. The other approach combines this procedure with intravenous thrombolysis, which is the administration of a clot-dissolving medication through a vein. In this study, the medication used for this process is tenecteplase. Participants will be assigned to receive either the combination of the medication and the procedure or just the procedure alone.

During the study, the effectiveness of the treatments will be observed by monitoring how well patients can perform daily activities and move independently. Doctors will also use imaging techniques like diffusion weighted imaging and fluid attenuated inversion recovery, which are special types of MRI scans used to look at the brain, to evaluate the extent of the brain injury. Safety will be monitored closely to check for any complications such as intracranial hemorrhage, which is bleeding inside the skull.