This study focuses on patients with ulcerative colitis, a condition that causes inflammation and sores in the digestive tract. The research compares two different treatment approaches for people newly diagnosed with moderate to severe forms of this disease who have not responded well enough to previous treatments.
The study evaluates two treatment options. The first treatment uses mirikizumab, a new type of medicine that is given either as an injection under the skin or through an intravenous infusion. The second treatment approach uses a combination of azathioprine (a medication that reduces immune system activity) and glucocorticoids (anti-inflammatory medications taken by mouth). The purpose is to determine if mirikizumab is more effective than the standard treatment with azathioprine and glucocorticoids in controlling the disease.
The treatment period lasts for 52 weeks (one year). During this time, patients will receive either mirikizumab or the combination of azathioprine and glucocorticoids, depending on which treatment group they are assigned to. Throughout the study, doctors will monitor how well the treatments are working and how they affect the patients’ condition.



Germany