This study is designed to compare how the body absorbs and uses two different forms of the medication celecoxib. The research focuses on conditions such as acute pain, which is sudden and short-term pain, as well as dysmenorrhea, commonly known as painful menstrual cramps, and various musculoskeletal and connective tissue disorders involving the muscles and joints. The investigation will compare a liquid version of the medication, known as celecoxib oral suspension, against the standard Celebrex capsules. Additionally, some participants may receive heparin, a medication typically used to prevent blood clots, as part of their background care.

The purpose of the study is to evaluate the bioavailability, which refers to the amount of a drug that enters the bloodstream and becomes available to produce an effect, and to see how eating food influences this process. During the trial, participants will receive a single dose of the medication under different conditions. This includes periods where they have not eaten, known as a fasted state, and periods after consuming a meal, known as a fed state. By comparing these different scenarios, researchers can determine if the liquid form works similarly to the capsule form and how food intake affects the medication’s performance.