A study of the humanised IgG1 lalaps-yte monoclonal antibody against lysophosphatidic acid receptor 1 to treat adults with idiopathic pulmonary fibrosis

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What is this study about?

This study focuses on individuals with Idiopathic Pulmonary Fibrosis, a condition where the lungs become scarred and thickened over time, making it harder to breathe. The goal of the study is to evaluate the safety and effectiveness of a new investigational medicine called ABBV-142. This treatment is a humanised igg1 lalaps-yte monoclonal antibody against lysophosphatidic acid receptor 1, which is a type of protein-based medicine designed to target specific processes in the body. ABBV-142 will be given to participants through intravenous administration, meaning it is delivered directly into a vein as a solution for injection/infusion.

During the study, some participants will receive the active medicine, while others will receive a placebo. The research involves monitoring how the medicine affects the body over a period of time to see if it can change the way the disease progresses. The course of the study includes regular check-ups to observe any changes in health or how the lungs are functioning.

Who Can Join the Study?

  • You must be at least 40 years old.
  • You must have been diagnosed with Idiopathic Pulmonary Fibrosis, which is a condition that causes scarring of the lungs, within the last 7 years.
  • Your diagnosis must be confirmed by a doctor using a high-resolution Computed Tomography (HRCT) scan, which is a detailed type of X-ray that shows clear images of the lungs, taken within the last 12 months.
  • Your lung scans must show a specific pattern of scarring known as Usual Interstitial Pneumonia (UIP) or probable UIP, which are common patterns seen in this lung disease.
  • If your scan results are unclear, your diagnosis may still be accepted if it was previously confirmed through a lung biopsy, which is a procedure where a small piece of lung tissue is removed to be examined under a microscope.
  • Regarding antifibrotics, which are medications used to slow down lung scarring, you must either have been taking a stable dose for at least 8 weeks or not taking them at all for at least 4 weeks.
  • Your Forced Vital Capacity (FVC), which is a measurement of the total amount of air you can exhale forcefully, must be at least 45% of what is considered normal for a person of your age and size.
  • Your diffusing capacity (DLCO), which is a test that measures how well your lungs move oxygen from the air into your blood, must be at least 25% of the predicted normal value.

Who Cannot Join the Study?

  • You have airways obstruction, which means your breathing tubes are partially blocked, measured by a specific test showing that the amount of air you can force out of your lungs in one second is too low.
  • You have experienced an acute IPF exacerbation, which is a sudden and rapid worsening of your lung condition, within the last 4 months or during the initial screening period.
  • You have had a lower respiratory tract infection, such as pneumonia (an infection in the lung tissue) or active tuberculosis (a serious bacterial infection), that required antimicrobials (medicines like antibiotics used to kill germs) within the last 4 weeks or during the screening period.

Where you can join this trial?

Verified and Recommended Sites

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Verified Sites

Other Sites

Site Name City Country Status
Karolinska University Hospital Solna Sweden
Semmelweis University Budapest Hungary
Azienda Ospedaliero Universitaria Di Modena Modena Italy
Institutul De Pneumoftiziologie Marius Nasta Bucharest Romania
Unidade Local De Saude De Loures-Odivelas EPE Loures Portugal
Hopital Beaujon Clichy France
Usycdbpsjj Oa Dfpdbeoh Debrecen Hungary
Lukxx Gzqpwfs Hiaikoqb Oj Aufinj Athens Greece
Sltwgrzhvyduckh Aw Stockholm Sweden
Uopzonjjpa Gqymjsw Hbtncooj Oa Ibmyhhmw Ioannina Greece
Hbclfbcw Vgju dmglpeeb Barcelona Spain
Alevrntnqd Piqpfuqj Hrgxvvqc Du Mgoldbmrr Marseille France
Hmcvoayb Cizeqf Dj Bxvcclhfa Barcelona Spain
Czubvc Hfrlylxgceg Rtezehlo Uhmggcvvjtlxe Dt Trohk Tours France
Chzqnv Hmlzdodnzfp Uqomcbhsdjumy Dy Medbhnpupyv Montpellier France
Udeapjogorsq Dg Szgcqvnp Du Cnuagvuwpl Santiago De Compostela Spain
Gmewrfb Uswmcenttm Hghrqbif Oe Pdnmlt Patras Greece
Mnjldkw Cozndq &svjebg Uenjurnubs Od Fkcaocbc Freiburg Im Breisgau Germany
Cjansh Hgahqfhydyp Udcipbjnyuqes Dr Rjxrue Rennes France
Hurdfqct Uquyxupdrcyuz Dm Ls Pmmczkke Madrid Spain
Hgpcbrxu Upzlpxktfiuvz Mbmeuld Dn Vnquwfqghr Santander Spain
Gosoqa Naeummydgl Tmeqbwgzfwqhp Gycruk Pebjwdwacstf Thessaloniki Greece
Cpny Cfiuho Coanfgc Aimxwybgw Btoaj Aupakhwqhc Braga Portugal
Urvcswuxjk Grypsxi Hskbfhru Os Helgdkfih Heraklion Greece
Uklxxtvyvw Mtepfjvyqxwo Hgdojskp Ffp Azsgca Tmdrhamiz Skcph Grihlg Elr Plovdiv Bulgaria
Akcadgx Opjintuddtavvqpcvqfqudqzl Pdcjaqhkssa Gi Rtuokjfqwhpg Mfzgj Dk Coocpvk Catania Italy
Daiintnjvlk Azp Coouyffhwcaa Chhxlm Cruxbx Lvyq Sofia Bulgaria
Kjjcrn Digqfbdzxi Donaustauf Germany
Slyxjmrv dp Pquvmlytfei Drd Lfkwqlg Dnaripqzd Selfg Oradea Romania
Hsschkno Uaivmjejmvxnn Qiswqumbpnv Mtpoao Pozuelo De Alarcon Spain
Pjbjurnll Iuceyplv Mfwforvh Mgkjfzcllxbo Slfnw Woehfpoikxkh I Aebppfkzkyqmo Warsaw Poland
Kgriepuy Kapnksai Gtzf Konstanz Germany
Ccasgv Rakcibpn Cyxwlnfx Dn Vtnquv Szjzor Verona Italy
Zryollcbvphky Bfn Bmjyk Gzfa Bad Berka Germany
Mxrrqnizxppfbphqsipsjrjttw Htzwqzthopwhnwqs Halle (Saale) Germany
Nxaoxltl Icyvolmtk Ow Tliofdshzglv Abl Lwmv Dbqdumcx Warsaw Poland
Vqnkmse Gcbpa I Cjrwpaivg Str jl Bydgoszcz Poland
Uygwfcv Liuux Dn Siemx Dj Mpdiazrzoc Emnify Senhora Da Hora Portugal
Mnthdcmzjirlo Hinssdnn fkc Acqpdl Twkbqsrds Hjdqf aky Birfp Ejv Pleven Bulgaria
Guxizfi Hefuzhkd Oh Chhme Aohf Eivvup Corfu Greece
Sfygsdgk Czaxca Jpkvedgm Mpghz Targu Mures Romania
Phbfno sy ca Sosnowiec Poland
Uwxfhgk Urnlsrrilw Hhfwylym Uppsala Sweden
Cptuww Higzuilimll Ulfvkduhupuqj Acuymd Pewonlnf Amiens France
Cptkof Hkfliwchoaw Lspd Sgx Pierre Benite France
Qoyqm Stfsip Ckzcvwsaj Hhlvochh &nzzmfx Sfrfegmhxca Uzxsdjyiet Hyefovhf &mndmvp Vfeafjz Ggzjhwyhfngqbeneee Gothenburg Sweden

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Bulgaria Bulgaria
Recruiting
01.04.2026
France France
Recruiting
01.04.2026
Germany Germany
Recruiting
01.04.2026
Greece Greece
Recruiting
01.04.2026
Hungary Hungary
Not yet recruiting
01.04.2026
Italy Italy
Not yet recruiting
01.04.2026
Poland Poland
Recruiting
01.04.2026
Portugal Portugal
Recruiting
01.04.2026
Romania Romania
Not yet recruiting
01.04.2026
Spain Spain
Not yet recruiting
01.04.2026
Sweden Sweden
Not yet recruiting
01.04.2026

Trial locations

ABBV-142 is an experimental medicine being tested to see if it can help treat people with idiopathic pulmonary fibrosis. It is an antibody delivered through a vein via an injection or infusion to target specific receptors in the body that may play a role in the disease.

Investigated Diseases:

Idiopathic Pulmonary Fibrosis – This is a condition where the lung tissue becomes thick and scarred over time. The scarring makes it difficult for the lungs to function properly and for oxygen to enter the bloodstream. It is characterized by the progressive buildup of fibrous tissue within the lungs. As the disease advances, the lungs become stiffer and less elastic. This process gradually reduces the amount of air the lungs can hold.

Trial ID:
2024-518013-25-00
Protocol code:
M25-268
Trial Phase:
Therapeutic exploratory (Phase II)

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