A study of the humanised IgG1 lalaps-yte monoclonal antibody against lysophosphatidic acid receptor 1 to treat adults with idiopathic pulmonary fibrosis

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What is this study about?

This study focuses on individuals with Idiopathic Pulmonary Fibrosis, a condition where the lungs become scarred and thickened over time, making it harder to breathe. The goal of the study is to evaluate the safety and effectiveness of a new investigational medicine called ABBV-142. This treatment is a humanised igg1 lalaps-yte monoclonal antibody against lysophosphatidic acid receptor 1, which is a type of protein-based medicine designed to target specific processes in the body. ABBV-142 will be given to participants through intravenous administration, meaning it is delivered directly into a vein as a solution for injection/infusion.

During the study, some participants will receive the active medicine, while others will receive a placebo. The research involves monitoring how the medicine affects the body over a period of time to see if it can change the way the disease progresses. The course of the study includes regular check-ups to observe any changes in health or how the lungs are functioning.

Who Can Join the Study?

  • You must be at least 40 years old.
  • You must have been diagnosed with Idiopathic Pulmonary Fibrosis, which is a condition that causes scarring of the lungs, within the last 7 years.
  • Your diagnosis must be confirmed by a doctor using a high-resolution Computed Tomography (HRCT) scan, which is a detailed type of X-ray that shows clear images of the lungs, taken within the last 12 months.
  • Your lung scans must show a specific pattern of scarring known as Usual Interstitial Pneumonia (UIP) or probable UIP, which are common patterns seen in this lung disease.
  • If your scan results are unclear, your diagnosis may still be accepted if it was previously confirmed through a lung biopsy, which is a procedure where a small piece of lung tissue is removed to be examined under a microscope.
  • Regarding antifibrotics, which are medications used to slow down lung scarring, you must either have been taking a stable dose for at least 8 weeks or not taking them at all for at least 4 weeks.
  • Your Forced Vital Capacity (FVC), which is a measurement of the total amount of air you can exhale forcefully, must be at least 45% of what is considered normal for a person of your age and size.
  • Your diffusing capacity (DLCO), which is a test that measures how well your lungs move oxygen from the air into your blood, must be at least 25% of the predicted normal value.

Who Cannot Join the Study?

  • You have airways obstruction, which means your breathing tubes are partially blocked, measured by a specific test showing that the amount of air you can force out of your lungs in one second is too low.
  • You have experienced an acute IPF exacerbation, which is a sudden and rapid worsening of your lung condition, within the last 4 months or during the initial screening period.
  • You have had a lower respiratory tract infection, such as pneumonia (an infection in the lung tissue) or active tuberculosis (a serious bacterial infection), that required antimicrobials (medicines like antibiotics used to kill germs) within the last 4 weeks or during the screening period.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Other Sites

Site Name City Country Status
Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Di Catania Catania Italy
Diagnostics And Consultation Center Convex Ltd. Sofia Bulgaria
Centro Ricerche Cliniche Di Verona S.r.l. Verona Italy
Azienda Ospedaliero Universitaria Di Modena Modena Italy
Zentralklinik Bad Berka GmbH Bad Berka Germany
Geniko Nosokomeio Thessalonikis George Papanikolaou Thessaloniki Greece
Unidade Local De Saude De Loures-Odivelas EPE Loures Portugal
CCAB Centro Clinico Academico Braga Associacao Braga Portugal
University General Hospital Of Heraklion Heraklion Greece
Vitamed Galaj I Cichomski Sp. j. Bydgoszcz Poland
Evangelische Lungenklinik Berlin Krankenhausbetriebs gGmbH Berlin Germany
Unidade Local De Saude De Matosinhos E.P.E. Senhora Da Hora Portugal
General Hospital Of Corfu Agia Eirini Corfu Greece
University Multiprofile Hospital For Active Treatment Saint Georgi EAD Plovdiv Bulgaria
University Of Debrecen Debrecen Hungary
University General Hospital Of Ioannina Ioannina Greece
Hospital Clinic De Barcelona Barcelona Spain
Karolinska University Hospital Solna Sweden
Semmelweis University Budapest Hungary
Hospital Universitario Quironsalud Madrid Pozuelo De Alarcon Spain
Centre Hospitalier Universitaire De Montpellier Montpellier France
Universidade De Santiago De Compostela Santiago De Compostela Spain
Institutul De Pneumoftiziologie Marius Nasta Bucharest Romania
General University Hospital Of Patras Patras Greece
Centre Hospitalier Universitaire Amiens Picardie Amiens France
Centre Hospitalier Universitaire De Rennes Rennes France
Klinikum Konstanz GmbH Konstanz Germany
Hopital Beaujon Clichy France
Queen Silvia Childrens Hospital – Sahlgrenska University Hospital – Vaestra Goetalandsregionen Gothenburg Sweden
Multi-profile Hospital for Active Treatment Heart and Brain EAD Pleven Bulgaria
Spitalul Clinic Judetean Mures Targu Mures Romania
Soedersjukhuset AB Stockholm Sweden
Mpdlvkeofbhdwcipjarfigxgdf Hrdxcdwnnvwznpbk Halle (Saale) Germany
Huxorsvo Ubjystkdeobhm Dd Ly Ppvrwpsc Madrid Spain
Holvnkqj Usulavzayrvrc Mtkgequ De Vkcmavegbq Santander Spain
Npuaxhtn Imtvgjvqm Ok Tabxkfiaubvx Apx Lbgj Djrhhtuj Warsaw Poland
Khmrce Dntyvyoxow Donaustauf Germany
Snjzpwty db Pctawnjihzj Dqr Lnbpoya Dopgiyoby Sfcnz Oradea Romania
Lkdbj Gvqciga Hqeazgxe Os Amadlq Athens Greece
Podelh Gngydjjs Gdyybx Meeifru Kuzksmbe snwt Sosnowiec Poland
Adpezkqphj Prnwvoas Hzyignlq Dh Mphpaqxjn Marseille France
Ugpnzmj Uqbcmjzglv Htbbrxzr Uppsala Sweden
Cxuzqn Hziauxvykap Reuqymwy Uejgpiyvbenny Dn Tnuqj Tours France
Pjsitserx Iwlgfdbq Mricwjvw Miqrypbbtiyj Spmru Wkfhumexvruy I Aiombvmeigzib Warsaw Poland
Hzghvlsb Vecw dfvkrojx Barcelona Spain

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Bulgaria Bulgaria
Not yet recruiting
01.04.2026
France France
Not yet recruiting
01.04.2026
Germany Germany
Not yet recruiting
01.04.2026
Greece Greece
Not yet recruiting
01.04.2026
Hungary Hungary
Not yet recruiting
01.04.2026
Italy Italy
Not yet recruiting
01.04.2026
Poland Poland
Not yet recruiting
01.04.2026
Portugal Portugal
Not yet recruiting
01.04.2026
Romania Romania
Not yet recruiting
01.04.2026
Spain Spain
Not yet recruiting
01.04.2026
Sweden Sweden
Not yet recruiting
01.04.2026

Trial locations

ABBV-142 is an experimental medicine being tested to see if it can help treat people with idiopathic pulmonary fibrosis. It is an antibody delivered through a vein via an injection or infusion to target specific receptors in the body that may play a role in the disease.

Investigated diseases:

Idiopathic Pulmonary Fibrosis – This is a condition where the lung tissue becomes thick and scarred over time. The scarring makes it difficult for the lungs to function properly and for oxygen to enter the bloodstream. It is characterized by the progressive buildup of fibrous tissue within the lungs. As the disease advances, the lungs become stiffer and less elastic. This process gradually reduces the amount of air the lungs can hold.

Trial ID:
2024-518013-25-00
Protocol code:
M25-268
Trial Phase:
Therapeutic exploratory (Phase II)

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