Wave Life Sciences Ireland Limited

Research activity includes Pi*ZZ alpha-1 antitrypsin deficiency, with attention to the clinical needs of adults affected by this inherited liver and lung disease. The funded studies reflect interest in disease-modifying approaches for a rare genetic disorder associated with protein misfolding and tissue injury.

• AATD
• Pi*ZZ genotype
• Inherited protein deficiency
• Hepatic and pulmonary disease

Clinical work in this area is centered on therapeutic development for a rare disease population with unmet need in both respiratory and hepatic care.