Diabetes and Glycaemic Control
Extensive work in type 2 diabetes and type 1 diabetes, with attention to blood glucose control, treatment intensification, and combinations involving basal insulin, GLP-1 receptor agonists, and SGLT2 inhibitors. Research also includes paediatric type 2 diabetes and diabetes-related complications.
- HbA1c reduction
- Insulin icodec
- Oral semaglutide
- Diabetic retinopathy
Clinical interest extends to metabolic control across age groups, including adolescents and children, with studies touching on diabetes management alongside excess body weight.
Obesity and Weight Management
Focused research in obesity, overweight, and related metabolic risk states, including weight reduction and long-term weight maintenance in adults, adolescents, and children. Trials also cover obesity linked with type 2 diabetes, obstructive sleep apnoea, knee osteoarthritis, and post-menopausal obesity.
- Cagrilintide
- CagriSema
- Semaglutide
- Liraglutide
Research includes metabolic and appetite-related outcomes in adults and paediatric populations with excess body weight.
Cardiovascular, Renal, and Inflammatory Disease
Work spans heart failure, acute myocardial infarction, atherosclerotic cardiovascular disease, cardiometabolic disease, and chronic kidney disease, often in the setting of systemic inflammation. Studies also include transthyretin amyloid cardiomyopathy and cardiovascular risk reduction.
- Ziltivekimab
- ATTR cardiomyopathy
- Major adverse cardiovascular events
- Chronic kidney disease progression
Therapeutic interest includes inflammatory pathways in cardiovascular and renal disease, as well as outcomes linked to cardiac function and vascular injury.
Haematology and Blood Disorders
Research activity includes inherited bleeding disorders such as haemophilia A and haemophilia B, with and without factor VIII inhibitors. Studies also address sickle cell disease and thalassaemia.
- Concizumab
- Mim8
- Bleeding prevention
- Sickle cell disease
The portfolio reflects interest in prophylaxis, bleeding control, and the management of chronic haematologic complications across adult and paediatric populations.
Endocrine, Growth, and Rare Disease Areas
Additional research covers growth hormone deficiency, short stature, Turner syndrome, Noonan syndrome, and small for gestational age children. The sponsor also studies alzheimer’s disease, non-alcoholic steatohepatitis, alcohol-related liver disease, and hereditary haemochromatosis.
- Somapacitan
- Paediatric growth disorders
- NASH
- Mild cognitive impairment
These programmes include endocrine replacement, liver disease, and neurocognitive conditions, with interest in both common metabolic and less common inherited disorders.
