Sexually transmitted infections and post-exposure prophylaxis
Research activity centres on the prevention of bacterial sexually transmitted infections, including Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum, with a strong focus on doxycycline post-exposure prophylaxis in MSM and TGW populations living with HIV or using HIV-PrEP.
- doxyPEP for STI prevention
- Weekly-DoxyPEP and event-driven prophylaxis
- bacterial sexually transmitted infections in key populations
These studies also address antimicrobial resistance linked to doxycycline exposure in intestinal and rectal bacterial flora.
Antimicrobial resistance and intestinal microbiology
The sponsor investigates how antibiotic exposure influences Escherichia coli susceptibility in the gastrointestinal tract, with attention to shifts in minimum inhibitory concentration patterns and the emergence of reduced susceptibility after prophylactic use.
- Escherichia coli resistance patterns
- ciprofloxacin exposure and bacterial susceptibility
- rectal E. coli and doxycycline resistance
Work in this area links antibiotic prevention strategies with changes in commensal and colonising bacteria.
Rabies vaccination and immune response
Clinical research includes rabies prevention, comparing intradermal and intramuscular vaccination routes, pre-exposure prophylaxis schedules, and booster responses measured through rabies antibodies and skin-resident memory T cells.
- rabies pre-exposure prophylaxis
- intradermal and intramuscular vaccination routes
- booster immunogenicity and skin imprinting
Additional work includes vaccination experiences in children, with attention to pain and usability of injection techniques.
Yellow fever vaccination and cell-mediated immunity
The sponsor also studies yellow fever immunisation, comparing intradermal, subcutaneous, and intramuscular routes, with emphasis on immune imprinting and the generation of yellow fever virus-specific memory responses.
- yellow fever vaccination routes
- skin-resident memory T cells
- vaccination immunogenicity
These studies support understanding of route-dependent immune responses in traveller and preventive medicine contexts.
Chemsex-related drug use and behavioural health
Research activity extends to the reduction of craving and use of chemsex-related drugs, combining pharmacological and counselling-based approaches in adults affected by problematic stimulant and related substance use.
- chemsex-associated drug craving
- semaglutide in behavioural support
- counselling for substance-use reduction
This area connects sexual health with interventions targeting substance-related risk behaviour.
