Gynecologic Oncology
Clinical research in ovarian cancer, fallopian tube cancer, and primary peritoneal cancer includes advanced, recurrent, platinum-resistant, and HRD-guided treatment strategies, as well as studies in patients with disease involving the pelvis and peritoneum.
- Advanced and recurrent ovarian malignancies
- Platinum-resistant disease
- Pelvic exenteration in gynecologic cancer
- Pre-neoplastic vulvar and cervical lesions
- Vulvar Paget’s disease
Interest also extends to electrochemotherapy, pembrolizumab-based approaches, and biomarker-informed management of HPV-related and invasive gynecologic lesions.
Genitourinary and Renal Cancer
The sponsor supports studies in metastatic castration-resistant prostate cancer, metastatic renal cell carcinoma, urothelial cancer, and muscle-invasive bladder cancer, with attention to molecular features that may guide treatment selection.
- Prostate cancer with BRCA-negative or unknown status
- Renal cell carcinoma
- Urothelial carcinoma
- Bladder cancer
- DDR gene alterations
Research activity also includes immunotherapy combinations, platinum sensitivity, and surgical oncology questions in advanced urinary tract malignancies.
Thoracic, Colorectal, and Melanoma Oncology
Ongoing work covers EGFR-mutant non-small cell lung cancer, metastatic colorectal cancer with BRAF V600E mutation, and metastatic uveal melanoma, reflecting a strong focus on molecularly defined solid tumors.
- EGFR-mutant NSCLC
- BRAF V600E-mutated metastatic colorectal cancer
- Uveal melanoma
- HER2-positive breast cancer
- Targeted therapy and immunotherapy
These studies include biomarker-driven treatment in TP53-defined lung cancer and resistance monitoring in HER2-directed therapy.
Autoimmune, Neuromuscular, and Neuro-Oncology Disorders
Non-oncologic research includes generalized myasthenia gravis, refractory systemic autoimmune diseases, connective tissue disease-associated interstitial lung disease, and optic pathway glioma in children and young adults.
- Myasthenia gravis
- Systemic autoimmune disease
- Connective tissue disease-associated interstitial lung disease
- Optic pathway glioma
- Neuroimmunology
Additional interest is shown in CAR T-cell therapy, rituximab, and visual function preservation in pediatric neuro-oncology.
Cardiometabolic and Psychiatric Research
The portfolio also includes myocardial infarction with non-obstructive coronary arteries, treatment-resistant depression, obesity, and type 2 diabetes, indicating activity across cardiovascular, metabolic, and mental health domains.
- MINOCA
- Treatment-resistant depression
- Obesity
- Type 2 diabetes
- Precision medicine
Research in this area includes biomarker-based phenotyping, brain imaging of neurotransporter function, and treatment response assessment in metabolic disease.
