Fondation A De Rothschild

Stroke and Neurovascular Disorders

Clinical research in acute ischemic stroke, ischemic stroke with large core, and subarachnoid hemorrhage includes work on reperfusion, arterial recanalization, and functional recovery. The portfolio also covers cerebral arteriovenous malformations and treatment strategies for patients not eligible for interventional procedures.

  • Endovascular therapy
  • Mechanical thrombectomy
  • Recanalization
  • Functional outcome

These studies reflect a strong interest in acute cerebrovascular care and vascular brain injury.

Ophthalmology and Retinal Disease

The sponsor supports research in Coats’ disease, central retinal vein occlusions, and severe ocular surface injury, with attention to vision preservation and retinal vascular pathology. Trials also address inflammatory and angiogenic mechanisms affecting ocular outcomes.

  • Anti-VEGF therapy
  • Intravitreal treatment
  • Ocular surface burns
  • Visual acuity

Research activity in this area spans both urgent eye injury care and chronic retinal disorders.

Neuroimmunology and Autoimmune Neurological Disease

Studies in multiple sclerosis and myasthenia gravis focus on disease control, relapse prevention, and suppression of neurological activity. The research also includes strategies aimed at limiting progression from ocular symptoms to generalized disease.

  • Disease activity
  • Immunotherapy
  • Relapse prevention
  • Radiological monitoring

This area connects chronic autoimmune neurology with longer-term management of inflammatory nervous system disorders.

Epilepsy and Seizure Control

Research in focal epilepsy addresses seizure recurrence during medication adjustment and perioperative monitoring. The sponsor’s activity in this field is centered on improving seizure suppression in patients undergoing specialized neurological evaluation.

  • Cluster seizures
  • Anti-seizure medication
  • Video EEG monitoring
  • Seizure recurrence

These trials place emphasis on seizure stability in complex clinical settings.

Alzheimer’s Disease and Neurodegeneration

The portfolio also includes studies in Alzheimer’s disease involving interventions aimed at modifying neurological progression and supporting cognitive care. This area broadens the sponsor’s interest to chronic neurodegenerative conditions.

  • Cognitive decline
  • Neuroinflammation
  • Brain imaging
  • Neurological progression

Research in this field aligns with efforts to address long-term central nervous system disease burden.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study of cangrelor with mechanical thrombectomy in patients with acute ischemic stroke selected by perfusion imaging

    Recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    France
  • Study on the Effects of Dornase Alfa for Patients with Subarachnoid Hemorrhage to Improve Independence After 6 Months

    Recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    France
  • Study on Bevacizumab for Patients with Symptomatic Cerebral Arteriovenous Malformations

    Recruiting

    2 1 1
    Investigated drugs:
    France
  • Study on Corticosteroids and Rituximab to Prevent Worsening of Ocular Myasthenia Gravis in Newly Diagnosed Patients

    Recruiting

    3 1 1 1
    Investigated diseases:
    France
  • Study on the Effects of Annual vs. Semi-Annual Ocrelizumab Infusions in Patients with Active Multiple Sclerosis After 2 Years of Initial Treatment

    Recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    France
  • Study of Probenecid for Controlling Cluster Seizures in Patients with Focal Epilepsy During Pre-surgical Video-EEG Monitoring

    Not yet recruiting

    2 1 1
    France