Oncology and Haematologic Malignancies
Clinical research includes breast cancer, non-small cell lung cancer, prostate cancer, colorectal cancer, pancreatic cancer, ovarian cancer, urothelial carcinoma, thyroid cancer, and other solid tumours, with additional studies in glioma, neuroblastoma, and advanced hematologic malignancies.
- Metastatic and advanced solid tumours
- Genomically defined cancers
- Breast, lung, prostate, and gastrointestinal cancers
- Brain tumours and paediatric oncology
Research activity also covers tumour subtypes linked to KRAS, RET, FGFR3, IDH1, and IDH2 alterations.
Metabolic, Cardiovascular, and Renal Disorders
Studies focus on type 2 diabetes, type 1 diabetes, obesity, overweight, hypertension, atherosclerotic cardiovascular disease, heart failure with preserved ejection fraction, peripheral arterial disease, and chronic kidney disease.
- Diabetes and beta-cell preservation
- Weight management and obesity-related disease
- Cardiovascular risk reduction
- Kidney function and renal impairment
Additional interest includes lipoprotein(a) and broader lipid disorders in people at elevated cardiovascular risk.
Immunology, Inflammation, and Autoimmune Disease
The sponsor funds trials in rheumatoid arthritis, juvenile idiopathic arthritis, uveitis, atopic dermatitis, alopecia areata, hidradenitis suppurativa, Crohn’s disease, ulcerative colitis, and other inflammatory bowel diseases.
- Inflammatory arthritis
- Skin and hair autoimmune conditions
- Ocular inflammation
- Gastrointestinal immune-mediated disease
Research also extends to connective tissue diseases and immune system diseases across adult and paediatric populations.
Neurology, Neurodegeneration, and Migraine
Clinical programmes address Alzheimer disease, dementia, relapsing multiple sclerosis, sporadic amyotrophic lateral sclerosis, chronic migraine, and episodic migraine, alongside broader central nervous system diseases and neurocognitive disorders.
- Alzheimer’s disease and cognitive decline
- Multiple sclerosis
- Motor neuron disease
- Paediatric and adolescent migraine
Research interest includes disorders affecting the nervous system and neurodegenerative diseases across different stages of life.
Respiratory, Sleep, Pain, and Other Chronic Conditions
Additional studies cover asthma, chronic rhinosinusitis with nasal polyps, obstructive sleep apnea, osteoarthritis, chronic low back pain, neuropathic pain, stress urinary incontinence, nausea, and vomiting.
- Airway and allergic disease
- Sleep-disordered breathing
- Musculoskeletal pain and joint disease
- Urological symptoms and supportive care
Trial activity also includes chronic pain syndromes and other symptomatic conditions affecting daily function.
