Alzheimer’s disease and cognitive impairment
Clinical research includes early Alzheimer’s disease, mild cognitive impairment due to Alzheimer’s disease, mild Alzheimer’s disease dementia, and preclinical Alzheimer’s disease with elevated or intermediate amyloid. The portfolio also includes work in cognitive decline and long-term assessment of memory and functional change.
- Preclinical Alzheimer’s disease
- Early Alzheimer’s disease
- Intermediate amyloid and elevated amyloid
- Mild cognitive impairment
These studies focus on disease stages before and after clinical symptom onset, with interest in markers of brain amyloid burden and cognitive performance.
Breast cancer and HER2-directed oncology
Research activity covers HER2-positive and HER2-low metastatic breast cancer, alongside broader development in advanced solid tumors. The oncology portfolio reflects interest in treatment-resistant disease settings and tumor types with limited therapeutic options.
- HER2-positive metastatic breast cancer
- HER2-low metastatic breast cancer
- Advanced solid tumors
Additional activity extends to combination approaches in difficult-to-treat breast cancer populations.
Gastrointestinal and liver cancer
The sponsor funds studies in colorectal cancer and hepatocellular carcinoma, with related interest in other advanced solid tumors. These areas include tumors with high unmet need in both metastatic and previously treated settings.
- Colorectal cancer
- Hepatocellular carcinoma
- Metastatic solid tumors
Research also includes combination-focused oncology programs across multiple tumor types, including melanoma, endometrial cancer, and non-small cell lung cancer.
Gynecologic and thoracic malignancies
Clinical interest extends to endometrial cancer, platinum-resistant ovarian cancer, triple-negative breast cancer, and non-small cell lung cancer adenocarcinoma. These programs address aggressive disease subtypes and advanced tumor biology.
- Endometrial cancer
- Platinum-resistant ovarian cancer
- Triple-negative breast cancer
- Non-small cell lung cancer adenocarcinoma
The oncology portfolio includes both single-tumor and multi-tumor development across gynecologic and thoracic cancers.
Epilepsy in pediatric populations
Research includes childhood epilepsy and seizure control in children receiving antiepileptic treatment. The therapeutic focus is on epileptic syndromes and maintenance of seizure reduction across pediatric cohorts.
- Childhood epilepsy
- Seizure frequency
- Pediatric epileptic syndromes
This area reflects sustained interest in neurological disorders affecting children and adolescents.
