Centessa Pharmaceuticals UK Limited

Sleep-Wake Disorders

Clinical research activity includes narcolepsy and idiopathic hypersomnia, with a focus on symptoms linked to excessive daytime sleepiness and impaired wakefulness. The trials also address long-term treatment considerations in these central disorders of hypersomnolence.

  • Narcolepsy
  • Idiopathic hypersomnia
  • Excessive daytime sleepiness
  • Wakefulness regulation

Research in this area is centered on therapeutic options for chronic sleep-related conditions that affect alertness and daily functioning.

Oncology

The sponsor also funds studies in advanced solid tumors, reflecting interest in difficult-to-treat malignancies across multiple cancer types. This includes clinical evaluation in patients with progressed disease and unmet treatment needs.

  • Advanced solid tumors
  • Malignant neoplasms
  • Antitumor activity
  • Oncology therapeutics

The oncology portfolio is directed toward investigational approaches for tumor control in advanced-stage disease.

Neurology

Trial activity spans central nervous system-related indications, particularly disorders of sleep and arousal. The clinical focus connects neurological regulation of sleep with persistent impairment in daytime functioning.

  • Central nervous system disorders
  • Sleep regulation
  • Arousal pathways
  • Neurological symptoms

These studies place emphasis on neurological mechanisms relevant to maintaining stable wakefulness and reducing disabling sleepiness.

Clinical Development in Rare and Specialized Conditions

The sponsor’s research footprint includes specialized therapeutic areas with limited treatment options, covering both rare sleep disorders and advanced cancer settings. The work is distributed across multiple active countries and collaborating sites.

  • Rare sleep disorders
  • Specialty therapeutics
  • Multicountry clinical research
  • Collaborative trial sites

Current studies reflect a concentrated interest in targeted clinical programs for distinct patient populations.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Long-term Safety Study of ORX750 for Patients with Narcolepsy and Idiopathic Hypersomnia Who Completed a Previous ORX750 Trial

    Recruiting

    1 1
    Investigated diseases:
    Investigated drugs:
    France Italy Spain
  • Study on the Safety and Effects of ORX750 for Patients with Narcolepsy and Idiopathic Hypersomnia

    Recruiting

    Investigated diseases:
    Investigated drugs:
    France Italy Spain