University Medical Center Hamburg-Eppendorf

At University Medical Center Hamburg-Eppendorf, a major share of research focuses on oncology and hematologic malignancies, including leukemia, lymphoma, multiple myeloma, and a wide range of solid tumors. These studies are designed to test new treatment approaches, improve response rates, and better match therapy to tumor biology.

• Acute and chronic leukemias, including acute myeloid leukemia and acute lymphoblastic leukemia
• Lymphomas, such as diffuse large B-cell lymphoma, mantle cell lymphoma, and Hodgkin lymphoma
• Breast cancer, prostate cancer, lung cancer, and other advanced solid tumors
• Trials evaluating new immunotherapies, targeted treatments, and combination strategies

The site is especially active in studies aiming to improve survival for difficult-to-treat cancers and to refine treatment selection for patients with advanced or relapsed disease.

Research in immunology and transplant medicine covers conditions where the immune system is overactive, misdirected, or needs careful control after transplantation. The trials explore better ways to manage rejection, reduce inflammation, and relieve symptoms in chronic immune-mediated diseases.

• Kidney transplant and solid organ transplantation, including rejection-related complications
• Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome
• Inflammatory conditions including ulcerative colitis, psoriasis, and atopic dermatitis
• Studies testing immune-modulating therapies and approaches to improve long-term disease control

This portfolio reflects a strong interest in balancing effective immune suppression with safety, particularly in patients who require long-term treatment.

The Klinik für Intensivmedizin contributes to research in cardiovascular disease, heart failure, atrial fibrillation, and vascular disease, alongside studies in critical illness. These trials aim to improve prevention, diagnosis, and treatment outcomes in patients with serious heart and circulation problems.

• Heart failure, myocardial infarction, and cardiomyopathy
• Atrial fibrillation, aortic stenosis, and other cardiac rhythm or valve disorders
• Stroke, thrombosis, and vascular disease
• Intensive care research on severe infection, shock, and recovery after major illness

Across these studies, the goal is often to reduce complications and improve survival in high-risk patients treated at University Medical Center Hamburg-Eppendorf.

A substantial research area covers kidney disease, proteinuric glomerular disorders, kidney transplantation, and related urinary conditions. The trials are focused on slowing disease progression, protecting kidney function, and improving outcomes after transplant.

• Chronic kidney disease, acute kidney injury, and proteinuria
• Focal segmental glomerulosclerosis, IgA nephropathy, and other glomerular diseases
• Kidney transplant rejection and post-transplant immune complications
• Studies evaluating treatments that preserve kidney function and reduce long-term complications

This field includes both adult and pediatric research, reflecting a broad interest in renal health across age groups.

The site also supports research in neurological disorders and mental health, including conditions that affect movement, cognition, and brain function. These trials commonly aim to improve symptom control, functional outcomes, or recovery after neurological injury.

• Stroke, multiple sclerosis, and epilepsy-related or other central nervous system disorders
• Glioblastoma, medulloblastoma, and other brain tumors
• Posttraumatic stress disorder and treatment-resistant depression
• Research on symptom relief, disease progression, and quality of life

These studies combine clinical care with efforts to better understand how neurological and psychiatric conditions can be treated more effectively.

Pediatric and rare disease studies form another important part of the research program, with attention to genetic disorders, rare metabolic diseases, and childhood cancers. The aim is often to improve long-term outcomes in conditions with limited treatment options.

• Children’s cancers such as acute lymphoblastic leukemia, neuroblastoma, and sarcomas
• Rare inherited disorders including Fabry disease, mucopolysaccharidoses, and phenylketonuria
• Developmental and neuromuscular diseases such as Duchenne muscular dystrophy and spinal muscular atrophy
• Trials designed to test new therapies and support better disease management in children

This area highlights the center’s role in research for rare, complex, and often lifelong conditions requiring specialized care.

Research in respiratory medicine, infectious disease, and systemic inflammation addresses both chronic and acute conditions. The studies look at ways to improve treatment for infections, lung fibrosis, and other inflammatory disorders that can seriously affect breathing and overall health.

• Idiopathic pulmonary fibrosis and other progressive lung diseases
• COVID-19, sepsis, and bacterial or viral infections
• Chronic hepatitis, primary sclerosing cholangitis, and other inflammatory organ diseases
• Trials focused on improving treatment effectiveness, symptom control, and prevention of disease progression

The research profile shows a strong interest in conditions where inflammation, infection, and organ damage intersect.