Unidade Local De Saude Do Alto Ave E.P.E.

This site in Guimaraes, Portugal is active in cardiology studies focused on cardiovascular diseases, including acute coronary syndrome, hypertension, atherosclerotic cardiovascular disease, heart failure, and transthyretin amyloid cardiomyopathy. The trials are designed to test new treatments, reduce major cardiac events, and improve long-term disease control.

• Preventing heart attacks, stroke, and other major cardiovascular events
• Evaluating therapies for heart failure and cardiomyopathy
• Studying lipid-lowering and risk-reduction strategies in high-risk patients

Research here also includes imaging-based assessment of treatment response and studies aimed at better understanding cardiac function and disease progression.

A major share of the research landscape covers neoplasms, especially breast cancer, gastric and gastroesophageal junction cancer, non-small cell lung cancer, small cell lung cancer, metastatic colorectal cancer, and urothelial carcinoma. These trials are centered on evaluating new targeted therapies and combinations intended to improve survival and disease control.

• Testing targeted approaches in HER2-positive and hormone receptor-positive breast cancer
• Assessing new treatment options for advanced gastric cancer and GEJ adenocarcinoma
• Studying novel strategies for advanced lung cancer and metastatic solid tumors

The site’s oncology portfolio reflects a strong interest in personalized medicine, with studies aimed at improving treatment effectiveness and delaying cancer recurrence.

Clinical trials in digestive system diseases include Crohn’s disease, ulcerative colitis, non-alcoholic steatohepatitis, primary sclerosing cholangitis, and primary biliary cholangitis. The research is focused on improving symptom control, reducing inflammation, and testing treatments that may slow disease progression or improve liver health.

• Evaluating therapies for inflammatory bowel disease
• Studying treatment options for NASH and other chronic liver conditions
• Assessing long-term safety and effectiveness of emerging digestive disease therapies

This area includes work on both gastrointestinal inflammation and metabolic liver disease, showing broad interest in chronic digestive and hepatology research.

The site also supports trials in respiratory tract diseases, including chronic obstructive pulmonary disease, severe asthma, bronchiectasis, pneumonia, and chronic rhinosinusitis. These studies aim to improve breathing symptoms, lower exacerbation rates, and assess new anti-inflammatory or supportive therapies.

• Testing treatments for COPD and asthma control
• Evaluating therapies to reduce flare-ups and improve lung function
• Studying approaches for sinus and airway inflammation

Research in this field spans chronic lung disease and upper-airway disorders, with a focus on better day-to-day symptom management.

Trials in nutritional and metabolic diseases include obesity, type 2 diabetes, familial chylomicronemia syndrome, and dyslipidemia. These studies are designed to evaluate therapies that may improve metabolic health, reduce cardiovascular risk, and protect against complications such as diabetic eye disease.

• Exploring treatments for obesity and metabolic risk
• Assessing therapies for type 2 diabetes and related complications
• Studying lipid and triglyceride lowering strategies

The metabolic portfolio connects closely with cardiovascular research, reflecting the overlap between blood sugar control, weight management, and heart health.

Research in nervous system diseases and mental disorders includes Alzheimer’s disease, Parkinson’s disease, migraine, multiple sclerosis, and psychosis related to dementia. These trials are aimed at improving symptoms, preserving function, and evaluating new options for cognitive and behavioral conditions.

• Studying treatments for Alzheimer’s-related cognitive and behavioral symptoms
• Evaluating options for Parkinson’s disease and migraine
• Assessing therapies for neurologic recovery after stroke or brain injury

This area includes both neurodegenerative disease and symptom-focused care, with an emphasis on quality of life and long-term management.

The site conducts studies in immune system diseases, musculoskeletal diseases, and skin and connective tissue diseases, including rheumatoid arthritis, systemic lupus erythematosus, hidradenitis suppurativa, psoriasis, and ulcerative colitis. These trials generally aim to reduce inflammation, relieve symptoms, and improve long-term disease control.

• Testing new therapies for chronic autoimmune inflammation
• Evaluating treatments for rheumatoid arthritis and lupus
• Studying options for psoriasis and other inflammatory skin conditions

The research portfolio highlights a broad interest in immune-driven diseases that affect the joints, skin, and internal organs.