Hematology and Blood Disorders

At Umbal – Prof. D-R Stoyan Kirkovich AD, the Department of Clinical Hematology supports a strong portfolio in hemic and lymphatic diseases, with research focused on acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, myelofibrosis, and thrombocytopenia. These studies are designed to test new treatment options, improve disease control, and reduce complications for patients with blood cancers and related disorders.

  • Acute myeloid leukemia and chronic lymphocytic leukemia studies evaluating new cancer therapies
  • Myelofibrosis and polycythemia vera research aimed at improving symptom control and long-term outcomes
  • Immune thrombocytopenia and moderate thrombocytopenia trials assessing better ways to manage low platelet counts
  • Thalassemia studies focused on reducing transfusion burden and supporting blood health

This research area reflects a broad effort to advance care for patients with complex hematologic diseases through more effective and better-tolerated treatment strategies.

Kidney Disease, Metabolism, and Cardiovascular Risk

The site also has active research in nutritional and metabolic diseases, cardiovascular diseases, and pathological conditions, especially chronic kidney disease, proteinuria, heart failure, atherosclerotic cardiovascular disease, and severe hypertriglyceridemia. These trials are generally aimed at slowing disease progression, lowering cardiovascular risk, and improving long-term organ protection.

  • Chronic kidney disease and proteinuria studies exploring better kidney-protective care
  • Heart failure and atherosclerotic cardiovascular disease trials assessing ways to reduce major cardiac events
  • Severe hypertriglyceridemia and obesity research targeting metabolic risk reduction
  • Dialysis-related studies focused on improving outcomes in patients with advanced kidney disease

This area combines kidney, cardiovascular, and metabolic research to help address conditions that often overlap in the same patients.

Autoimmune, Inflammatory, and Skin Diseases

A major part of the research program centers on immune system diseases and skin and connective tissue diseases, including hidradenitis suppurativa, psoriasis, vitiligo, ulcerative colitis, asthma, and chronic urticaria. The purpose of these trials is to evaluate new therapies, maintain disease control over time, and improve symptoms that affect daily life.

  • Hidradenitis suppurativa studies testing new options for a painful chronic skin condition
  • Psoriasis, vitiligo, and psoriatic arthritis research aimed at improving immune-mediated skin and joint disease control
  • Ulcerative colitis trials evaluating treatments for inflammatory bowel disease
  • Chronic inducible urticaria and asthma studies focused on symptom relief and better disease management

These studies show a broad interest in inflammatory disorders where the goal is often to reduce flare-ups, improve comfort, and support longer-term stability.

Liver, Infection, and Respiratory Research

The clinical trial portfolio at Umbal – Prof. D-R Stoyan Kirkovich AD also includes virus diseases, bacterial infections, and respiratory tract diseases, with studies in chronic hepatitis B, chronic hepatitis D, invasive candidiasis, acute bacterial skin infections, and chronic rhinosinusitis without nasal polyps. These trials are mainly aimed at improving infection control, testing antiviral strategies, and easing persistent respiratory symptoms.

  • Chronic hepatitis B and chronic hepatitis D studies exploring new antiviral approaches
  • Invasive candidiasis and bacterial skin infection research assessing better anti-infective treatment options
  • Chronic rhinosinusitis trials focused on reducing ongoing nasal and sinus symptoms
  • Respiratory and infectious disease research supporting improved patient recovery

This work reflects a practical focus on both long-standing viral illness and serious infections, where better treatment choices can make a meaningful difference in outcomes.

Neurology, Psychiatry, and Symptom Management

The site contributes to research in nervous system diseases and mental disorders, including Alzheimer’s disease psychosis, agitation associated with Alzheimer’s dementia, schizophrenia, and bipolar I disorder. In addition, some studies address postoperative pain and other symptom-focused needs, with the overall aim of improving comfort, behavior, and quality of life.

  • Alzheimer’s-related psychosis and agitation trials evaluating ways to better manage difficult neuropsychiatric symptoms
  • Schizophrenia research focused on long-term symptom control and tolerability
  • Bipolar mania studies assessing treatment effectiveness during acute episodes
  • Postoperative pain research aimed at improving short-term pain relief after surgery

This area highlights the site’s interest in both psychiatric care and symptom relief, with studies designed to support patients facing challenging neurological and behavioral conditions.