Stichting Radboud University Medical Center

At Stichting Radboud University Medical Center in Nijmegen, the orthopedics research program includes studies focused on prosthetic joint infection, a serious complication affecting joint replacement patients. This work sits at the intersection of musculoskeletal care and infection management, with trials designed to compare treatment strategies and improve how infected implants are managed.

• Evaluating whether targeted antibiotic treatment can work as well as standard combination therapy for infected joint prostheses
• Improving treatment choices for patients with staphylococcal prosthetic joint infection
• Supporting better outcomes in orthopedic infection care

The research aims to refine antibiotic therapy for joint infections and help identify effective, practical options for patients recovering from implant-related infection.

This site is also studying non-medullary thyroid carcinoma, especially cases with locally advanced or metastatic disease where standard radioiodine handling is limited. The trials explore ways to improve radioiodine uptake and strengthen treatment response in patients with harder-to-treat thyroid cancer.

• Testing whether digoxin can help restore radioiodine uptake in advanced thyroid cancer
• Exploring new approaches for patients with insufficient response to radioiodine-based treatment
• Advancing care for locally advanced and metastatic thyroid malignancies

These studies focus on finding a better therapeutic approach for thyroid cancer when conventional treatment is not enough.

The clinical research portfolio at Stichting Radboud University Medical Center also includes work in critical care, examining older ventilated patients who depend on intensive medical support. The main goal is to assess whether early use of dexmedetomidine can improve outcomes compared with usual sedation practice.

• Studying mortality in older critically ill patients receiving early sedative treatment
• Evaluating sedation strategies for mechanically ventilated patients
• Building evidence for safer and more effective critical care sedation

This research supports better decision-making in anesthesia and analgesia for patients requiring intensive support, with a focus on treatment effectiveness and patient survival.