St. Vinzenz-Hospital GmbH

At St. Vinzenz-Hospital GmbH in Cologne, clinical trials focus on cardiovascular diseases and related risk factors such as atherosclerotic cardiovascular disease, hypercholesterolemia, and myocardial infarction. The studies are designed to test new treatment approaches and better ways to lower cardiovascular risk in people with established heart disease.

• Evaluating therapies that lower LDL cholesterol in patients with ASCVD
• Studying treatments aimed at reducing lipoprotein(a) and major cardiovascular events
• Assessing the safety and long-term tolerability of pelacarsen in people with established cardiovascular disease

The research also includes efforts to reduce inflammation and prevent recurrent events after acute myocardial infarction, with the goal of improving treatment effectiveness and outcomes for patients at high cardiovascular risk.

Another key area at this hospital is research in acute coronary syndromes, especially ST-elevation myocardial infarction and non-ST-elevation myocardial infarction. These trials examine whether new therapies can be added to standard care to better protect patients after a heart attack.

• Testing ziltivekimab for reducing the risk of major adverse cardiovascular events after AMI
• Exploring anti-inflammatory strategies to improve recovery after myocardial infarction
• Supporting research on earlier intervention to lower the chance of repeat cardiovascular events

This work reflects a strong interest in both prevention and treatment of serious heart conditions, with a focus on improving outcomes for patients seen in the Department of Innere Medizin III - Kardiologie.