St. Elisabeth-Krankenhaus Leipzig

At St. Elisabeth-Krankenhaus Leipzig, a major focus is on breast cancer research, especially ER-positive, HER2-negative, and triple-negative disease. The trials are designed to test new treatment combinations and improve outcomes for people with early, locally advanced, or metastatic cancer.

• Evaluating new approaches for HR-positive/HER2-negative early breast cancer
• Studying treatment effectiveness in triple-negative breast cancer
• Assessing therapies for primary high-risk lobular breast cancer and advanced disease

This research includes efforts to strengthen endocrine therapy strategies, improve disease control, and test whether adding targeted or immune-based treatments can offer better protection against recurrence and progression.

The site also conducts important studies in non-small cell lung cancer, covering both newly diagnosed and previously treated disease. These trials explore whether newer immune and targeted therapies can improve survival and help patients with different molecular subtypes of lung cancer.

• Testing treatments for EGFR-mutated NSCLC
• Researching KRAS G12C-mutant and other advanced lung cancers
• Comparing immune-based and chemotherapy-based options for metastatic lung adenocarcinoma

The work at this Leipzig hospital is aimed at improving survival, refining treatment selection, and expanding options for patients with advanced respiratory tract diseases driven by cancer.

Another theme across the research portfolio is the use of biomarkers and molecular profiling to guide cancer care. These studies look at how tumor features such as circulating tumor DNA, receptor status, and mutation patterns can help tailor treatment more precisely.

• Using ctDNA to help guide adjuvant treatment decisions in colon cancer stage II
• Exploring molecular patterns linked to response and resistance in advanced breast cancer
• Assessing tumor-specific markers to better match therapy to disease behavior

This area of research reflects a broader effort to improve diagnostics and personalize care, helping clinicians choose treatments that are more likely to be effective for each patient.