Spaarne Gasthuis

At Spaarne Gasthuis, clinical research in hematology focuses on aggressive and relapsed blood cancers, with studies designed to improve survival, deepen remission, and reduce treatment-related harm.

• Trials in diffuse large B-cell lymphoma, mantle cell lymphoma, and other non-Hodgkin lymphomas
• Research in multiple myeloma, chronic lymphocytic leukemia, myelofibrosis, and polycythemia vera
• Testing new combinations and maintenance strategies to improve response and extend disease control
• Studies aimed at lowering cardiac toxicity and other side effects of standard cancer treatment

These projects reflect a strong interest in refining blood cancer care while making treatment more effective and better tolerated.

The site has a broad portfolio in oncology for colorectal cancer, gastric cancer, esophageal cancer, rectal cancer, and advanced solid tumors, with a clear emphasis on improving outcomes in both early and metastatic disease.

• Studies in colon cancer, rectal cancer, and colorectal liver metastases
• Research in gastric and esophagogastric cancer
• Trials exploring organ-preserving treatment, neoadjuvant approaches, and better recurrence prevention
• Work evaluating whether treatment intensification or de-escalation can maintain control while reducing toxicity

These trials are aimed at finding more personalized ways to treat gastrointestinal malignancies and preserve quality of life.

Research in breast cancer at Spaarne Gasthuis spans early-stage, metastatic, and hormone receptor-positive disease, with studies focused on recurrence prevention and treatment sequencing.

• ER-positive, HER2-negative early breast cancer
• HER2-positive breast cancer and triple-negative breast cancer
• Metastatic breast cancer trials evaluating endocrine therapy, targeted therapy, and immunotherapy combinations
• Studies addressing symptoms linked to hormone therapy, including vasomotor symptoms

This work aims to improve long-term disease control while making treatment easier to tolerate for people living with breast cancer.

The clinical trial program includes substantial work in prostate cancer and bladder cancer, especially in settings where new treatment strategies may improve survival or reduce the burden of therapy.

• Metastatic castration-resistant prostate cancer and low-volume metastatic castration-sensitive prostate cancer
• Muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer
• Studies testing new hormonal, immune-based, and bladder-sparing approaches
• Research looking at whether treatment can be safely shortened, switched, or personalized

These trials support more tailored care for urothelial and prostate malignancies, with attention to both effectiveness and side effects.

Beyond cancer, the site also contributes to studies in cardiovascular disease, obesity, diabetes, and chronic kidney disease, reflecting an interest in preventing major complications and improving long-term health.

• Acute myocardial infarction, atrial fibrillation, and broader atherosclerotic cardiovascular disease
• Heart failure, stroke, and venous thromboembolism
• Type 2 diabetes mellitus, obesity, and elevated lipoprotein(a)
• Kidney failure and advanced chronic kidney disease

These trials are designed to test new ways to prevent serious events and improve outcomes in common cardiometabolic conditions.

Clinical research here also extends to neurologic and immune-mediated diseases, with studies exploring better disease control, improved diagnosis, and more individualized treatment.

• Multiple sclerosis and mild cognitive impairment or dementia
• Plaque psoriasis and other inflammatory skin disease
• Immune system diseases and treatment personalization strategies
• Research focused on matching therapy intensity to patient needs and reducing unnecessary exposure

This area shows an emphasis on better long-term management of chronic inflammatory and neurologic disorders.

The trial portfolio at Spaarne Gasthuis also includes studies that improve diagnosis, symptom control, and reproductive health, showing a wider commitment to patient-centered care.

• Diagnostic research such as tau PET for better clinical assessment
• Supportive care studies in advanced cancer, including constipation prevention and symptom relief
• Infertility, unexplained subfertility, and preterm birth prevention
• Trials in pneumonia, influenza, and sepsis to improve acute care outcomes

These projects aim to make care more precise, reduce complications, and improve everyday well-being across a range of medical specialties.