Sorlandet Sykehus HF

At Sorlandet Sykehus HF the cardiology department runs studies designed to lower the risk of major cardiac events and to enhance long‑term heart health.

• Evaluating an LDL‑lowering agent for prevention of heart attacks and strokes
• Testing a self‑administered drug for early treatment of suspected acute myocardial infarction
• Comparing continued versus discontinued aspirin therapy after acute coronary syndrome
• Investigating a combination of vicadrostat and empagliflozin in patients with type 2 diabetes, hypertension and established cardiovascular disease
• Studying a novel therapy to slow progression of moderate calcific aortic valve stenosis

The site supports 11 active trials with six investigators, reflecting a strong focus on cardiovascular research in Norway.

Research on inflammatory eye disorders seeks safer and more effective options for patients with active thyroid eye disease.

• Comparing sirolimus with corticosteroids for treatment of active thyroid eye disease
• Assessing visual function outcomes following immunomodulatory therapy

These trials are coordinated within the ophthalmology unit of Sorlandet Sykehus HF and contribute to improving ocular care.

Oncology studies target aggressive lung cancers and aim to improve survival by integrating radiotherapy with systemic treatments.

• Adding thoracic radiotherapy to immunotherapy and chemotherapy in extensive‑stage small‑cell lung cancer
• Measuring one‑year overall survival and disease progression under the combined regimen

The cancer trial is part of a national effort to refine multimodal therapy for high‑risk lung malignancies.

Investigations focus on novel inhaled treatments to lessen the burden of chronic obstructive pulmonary disease (COPD).

• Evaluating the annualized rate of moderate to severe COPD exacerbations with an investigational inhaled medication
• Monitoring safety and tolerability in adults with eosinophilic COPD phenotype

These studies aim to provide clearer therapeutic pathways for patients experiencing frequent respiratory flare‑ups.

Physiological research examines how heart and lung function interact in diverse disease settings.

• Assessing peak VO2 improvement with ataciguat in patients with calcific aortic valve stenosis
• Evaluating the impact of intravenous iron on cardiovascular mortality in iron‑deficient chronic heart failure
• Studying QT interval changes after menopausal hormone therapy in genetically confirmed long QT syndrome

The interdisciplinary approach at Sorlandet Sykehus HF bridges cardiology, pulmonology, and metabolic research to deepen understanding of systemic physiology.