Saint Maria Hospital

At Saint Maria Hospital in Bucharest, clinical trials in rheumatology and immune system diseases focus on conditions such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, and Sjögren’s syndrome. These studies are designed to test new therapies and compare treatment options that may better control inflammation, improve symptoms, and support long-term disease management.

• Research on rheumatoid arthritis and related inflammatory joint disease
• Studies in psoriatic arthritis and non-radiographic axial spondyloarthritis
• Trials in systemic lupus erythematosus and other autoimmune disorders
• Evaluation of treatment effectiveness and safety in chronic immune-mediated disease

This area reflects a strong emphasis on improving care for people living with persistent autoimmune conditions, with investigators exploring both symptom relief and broader disease control.

A major part of the research program addresses musculoskeletal diseases and skin and connective tissue diseases, especially systemic sclerosis, diffuse cutaneous systemic sclerosis, and related fibrotic disorders. The trials aim to better understand disease progression and evaluate therapies that may improve skin involvement, lung function, and overall quality of life.

• Systemic sclerosis and diffuse cutaneous forms
• Studies of skin thickening, fibrosis, and organ involvement
• Testing new approaches to slow disease progression
• Assessment of safety and tolerability in long-term treatment

The site’s work in this field highlights the need for better options in complex connective tissue disease, where symptoms can affect both the skin and internal organs.

Trials at the Department of Rheumatology and Internal Medicine I also concentrate on lupus and Sjögren’s disease, including lupus nephritis and cutaneous forms of lupus. These studies are intended to evaluate whether emerging treatments can reduce disease activity, protect organ function, and offer more durable control of autoimmune symptoms.

• Systemic lupus erythematosus and cutaneous lupus erythematosus
• Lupus nephritis and renal response outcomes
• Sjögren’s syndrome and primary Sjögren’s disease
• Improving disease activity measures and long-term treatment safety

This research supports a broader effort to advance care for autoimmune diseases that can be difficult to manage and may affect multiple organs over time.

The site is also involved in studies of skin and connective tissue diseases such as dermatomyositis, psoriatic arthritis, and lupus-related skin disease. These trials are focused on testing new treatment strategies that may ease inflammation, improve skin and muscle symptoms, and help patients maintain daily function.

• Dermatomyositis and muscle-related inflammation
• Inflammatory skin disease linked to autoimmune conditions
• Psoriatic arthritis with joint and skin symptoms
• Evaluating whether therapies can improve symptom control and patient well-being

By spanning both skin and muscle disorders, this research contributes to a more complete understanding of autoimmune disease patterns and treatment response.

Beyond classic rheumatology, trials at Saint Maria Hospital include digestive system diseases such as non-alcoholic steatohepatitis, as well as immune-related conditions like ANCA-associated vasculitis and interstitial lung disease. These studies aim to improve diagnosis, evaluate treatment effectiveness, and expand options for patients with complex inflammatory disease.

• Non-alcoholic steatohepatitis and liver inflammation
• ANCA-associated vasculitis and systemic immune disease
• Interstitial lung disease linked to autoimmune disorders
• Research on safety, symptom control, and organ protection

This mix of studies shows a multidisciplinary focus that connects autoimmune medicine with internal medicine care, offering research opportunities across several chronic and often overlapping conditions.