A Phase 3 Study of Orelabrutinib to Delay Disability Progression in Patients with Non‑Active Secondary Progressive Multiple Sclerosis
- Substances:–
Poland- Participants:18–64 years
- Sponsor:Zenas Biopharma (USA) LLC
Rare diseases
Investigational molecules
Locations
Os. Zlotej Jesieni 1, 31-826 Cracow, Poland
Osrodek Badan Klinicznych Przy Szpitalu Specjalistycznym Im. Ludwika Rydygiera W Krakowie Sp. z o.o. in Cracow, Poland specialises in clinical trials of conditions such as Squamous cell carcinoma of head and neck, Cachexia, Cardiac failure, Non-small cell lung cancer metastatic, and other specialisations. This site conducts important research.
At Osrodek Badan Klinicznych Przy Szpitalu Specjalistycznym Im. Ludwika Rydygiera W Krakowie Sp. z o.o., clinical studies in musculoskeletal diseases focus on knee osteoarthritis and related chronic pain, with additional interest in weight-related joint burden. These trials are designed to test new symptom-relief options, improve daily function, and better understand treatment effectiveness for people living with long-term joint problems.
The site’s work in this area reflects a practical focus on easing discomfort and supporting movement in patients with common, disabling musculoskeletal conditions.
Research in cardiovascular diseases includes atrial fibrillation, stroke prevention, hypertension, heart failure, and venous thromboembolism. These studies aim to improve protection against clot-related events, reduce bleeding risk, and assess treatments that may help patients with high cardiovascular risk or established heart disease.
This portfolio shows a strong interest in better prevention and treatment approaches for major cardiovascular conditions that affect long-term health.
A large share of the research at this clinical research site centers on neoplasms, including breast cancer, lung cancer, head and neck cancer, prostate cancer, pancreatic cancer, bladder cancer, melanoma, and several types of lymphoma and leukemia. The trials mainly explore new therapies, combination treatments, and ways to improve survival or control disease after prior treatment.
Overall, the oncology program is broad and active, with studies aimed at improving outcomes for both newly diagnosed and previously treated patients.
Clinical trials in nervous system diseases include multiple sclerosis, myasthenia gravis, spinal muscular atrophy, and stroke-related conditions. The research is focused on easing symptoms, slowing disability progression, and exploring more effective ways to prevent neurological injury or relapse.
These studies support a wider effort to refine care for chronic neurological disorders that can significantly affect independence and quality of life.
The site also participates in trials for digestive system diseases, especially colorectal cancer, Crohn-related fistula, and pancreatic disease, as well as post-surgical digestive problems such as pancreatic exocrine insufficiency and post-gastrectomy nutritional issues. These studies are intended to improve treatment response, symptom control, and nutritional support.
This area combines cancer research with broader gastrointestinal care, reflecting a diverse set of digestive health priorities.
Studies in hemic and lymphatic diseases cover acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, and different forms of non-Hodgkin lymphoma and Hodgkin lymphoma. The main purpose is to assess new treatment combinations, improve remission rates, and support patients whose disease has returned or not responded to earlier therapy.
The hematology program at the Krakow site is centered on improving care for complex blood cancers through innovative and comparative research.
Research in immune system diseases includes multiple sclerosis and other conditions where immune activity affects the nervous system or overall health. These trials aim to reduce disease activity, limit progression, and evaluate treatments that may offer better long-term control of immune-mediated illness.
The research reflects a continued effort to refine therapies for patients with persistent immune-related conditions.
Trials in nutritional and metabolic diseases address obesity, cancer cachexia, and metabolic changes linked to chronic illness. The aim is to evaluate treatments that may help preserve body weight, support nutrition, and improve physical well-being in patients affected by cancer or heart disease.
These studies show an interest in the broader metabolic impact of serious illness, not just the primary diagnosis.
Some studies at the site span more than one specialty or address supportive care questions that do not fit neatly into a single category. These trials may focus on surgical bleeding management, infection prevention, or other practical clinical needs, with the goal of improving safety and everyday treatment outcomes.
Together, these projects add breadth to the site’s research profile and complement its disease-specific programs.
Clinical trials currently enrolling participants at this site.
PolandA study to evaluate the effects of zenagamtide on weight and pain in patients with overweight or obesity and knee osteoarthritis
PolandA study to evaluate the efficacy and safety of zenagamtide in people with overweight or obesity and knee osteoarthritis
PolandA study to evaluate the safety and how the body uses ublituximab injections in patients with multiple sclerosis
PolandA Study of Visugromab Compared to Placebo in Patients with Cancer-Related Cachexia to Test How Well It Works and How Safe It Is
PolandStudy of Zilebesiran Added to Standard Treatment to Reduce Heart Problems in Adults with High Blood Pressure and Heart Disease Risk
PolandStudy of NGM120 in patients with colorectal cancer and cancer cachexia: Evaluating effects on body weight
PolandStudy on the Effectiveness of Ublituximab and Drug Combination for Patients with Relapsing Multiple Sclerosis
PolandStudy on the Effectiveness of GP2 and Sargramostim for HER2 Positive Breast Cancer Patients with Residual Disease or High-Risk After Standard Therapy
PolandStudy on the Long-term Safety and Efficacy of Pembrolizumab and Lenvatinib for Patients with Advanced Tumors
PolandStudy of BGB-43395 with letrozole versus CDK4/6 inhibitor drug combination with letrozole in patients with untreated advanced HR‑positive HER2‑negative breast cancer
PolandStudy of Zenagamtide (NNC0487-0111) versus placebo in patients with heart failure with preserved or mildly reduced ejection fraction and obesity
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